BMP7
Gene Information
- Official Symbol: BMP7
- Official Name: bone morphogenetic protein 7
- Aliases and Previous Symbols: N/A
- Entrez ID: 655
- UniProt: P18075
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone, kidney and brown adipose tissue development. Additionally, this protein induces ectopic bone formation and may promote fracture healing in human patients. [provided by RefSeq, Jul 2016].
- UniProt Summary: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.
Pfam Domains GO Terms
Pfam Domains
| TGFb propeptide |
| TGF beta |
GO Terms
| nephrogenic mesenchyme morphogenesis |
| allantois development |
| positive regulation of neural crest cell differentiation |
| kidney mesenchymal cell proliferation |
| metanephric mesenchyme morphogenesis |
| negative regulation of glomerular mesangial cell proliferation |
| monocyte aggregation |
| negative regulation of glomerulus development |
| positive regulation of hyaluranon cable assembly |
| nephrogenic mesenchyme development |
| positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis |
| neural fold elevation formation |
| metanephric mesenchymal cell proliferation involved in metanephros development |
| regulation of hyaluranon cable assembly |
| kidney mesenchyme morphogenesis |
| regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis |
| negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis |
| regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis |
| negative regulation of prostatic bud formation |
| negative regulation of somatic stem cell population maintenance |
| negative regulation of cell proliferation involved in kidney development |
| regulation of neural crest cell differentiation |
| negative regulation of apoptotic process involved in development |
| negative regulation of apoptotic process involved in morphogenesis |
| regulation of branching involved in prostate gland morphogenesis |
| regulation of prostatic bud formation |
| regulation of somatic stem cell population maintenance |
| negative regulation of stem cell population maintenance |
| neural fold formation |
| chorio-allantoic fusion |
| cell proliferation involved in metanephros development |
| pericardium morphogenesis |
| extraembryonic membrane development |
| cell proliferation involved in kidney development |
| regulation of removal of superoxide radicals |
| regulation of glomerular mesangial cell proliferation |
| negative regulation of mesenchymal cell apoptotic process |
| leukocyte aggregation |
| BMP receptor binding |
| embryonic skeletal joint morphogenesis |
| regulation of apoptotic process involved in morphogenesis |
| regulation of apoptotic process involved in development |
| regulation of mesenchymal cell apoptotic process |
| metanephric mesenchyme development |
| regulation of cell proliferation involved in kidney development |
| embryonic skeletal joint development |
| regulation of glomerulus development |
| negative regulation of morphogenesis of an epithelium |
| negative regulation of kidney development |
| positive regulation of heterotypic cell-cell adhesion |
| mesenchymal cell proliferation |
| branching involved in salivary gland morphogenesis |
| kidney mesenchyme development |
| morphogenesis of an epithelial fold |
| pericardium development |
| endocardial cushion formation |
| positive regulation of stem cell differentiation |
| labyrinthine layer morphogenesis |
| negative regulation of NIK/NF-kappaB signaling |
| negative regulation of striated muscle cell apoptotic process |
| pharyngeal system development |
| regulation of heterotypic cell-cell adhesion |
| embryonic placenta morphogenesis |
| negative regulation of embryonic development |
| embryonic camera-type eye morphogenesis |
| regulation of stem cell population maintenance |
| positive regulation of cardiocyte differentiation |
| salivary gland morphogenesis |
| positive regulation of peptidyl-threonine phosphorylation |
| response to vitamin D |
| heart trabecula morphogenesis |
| salivary gland development |
| regulation of superoxide metabolic process |
| negative regulation of animal organ morphogenesis |
| regulation of response to reactive oxygen species |
| embryonic eye morphogenesis |
| endocardial cushion morphogenesis |
| regulation of animal organ formation |
| embryonic camera-type eye development |
| negative regulation of muscle cell apoptotic process |
| positive regulation of bone mineralization |
| regulation of striated muscle cell apoptotic process |
| negative regulation of mitotic nuclear division |
| regulation of heart morphogenesis |
| transforming growth factor beta receptor binding |
| negative regulation of Notch signaling pathway |
| endocardial cushion development |
| exocrine system development |
| regulation of peptidyl-threonine phosphorylation |
| trabecula morphogenesis |
| labyrinthine layer development |
| positive regulation of epithelial to mesenchymal transition |
| positive regulation of biomineralization |
| positive regulation of biomineral tissue development |
| negative regulation of nuclear division |
| positive regulation of pathway-restricted SMAD protein phosphorylation |
| morphogenesis of an epithelial sheet |
| mesenchyme morphogenesis |
| regulation of cardiocyte differentiation |
| leukocyte cell-cell adhesion |
| regulation of kidney development |
| negative regulation of reproductive process |
| SMAD protein signal transduction |
| regulation of morphogenesis of a branching structure |
| positive regulation of osteoblast differentiation |
| regulation of pathway-restricted SMAD protein phosphorylation |
| embryonic pattern specification |
| mesoderm formation |
| regulation of muscle cell apoptotic process |
| mesoderm morphogenesis |
| epithelial to mesenchymal transition |
| positive regulation of dendrite development |
| cardiac septum morphogenesis |
| negative regulation of MAP kinase activity |
| regulation of bone mineralization |
| regulation of cellular response to oxidative stress |
| positive regulation of animal organ morphogenesis |
| negative regulation of NF-kappaB transcription factor activity |
| odontogenesis of dentin-containing tooth |
| regulation of epithelial to mesenchymal transition |
| metanephros development |
| positive regulation of ossification |
| regulation of response to oxidative stress |
| ureteric bud development |
| mesonephric tubule development |
| embryonic placenta development |
| response to vitamin |
| mesonephric epithelium development |
| BMP signaling pathway |
| mesonephros development |
| regulation of biomineralization |
| regulation of biomineral tissue development |
| embryonic skeletal system morphogenesis |
| primary neural tube formation |
| gland morphogenesis |
| regulation of Notch signaling pathway |
| dendrite development |
| positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| cellular response to BMP stimulus |
| response to BMP |
| neural tube formation |
| cardiac septum development |
| regulation of NIK/NF-kappaB signaling |
| formation of primary germ layer |
| camera-type eye morphogenesis |
| regulation of osteoblast differentiation |
| negative regulation of vasculature development |
| regulation of stem cell differentiation |
| steroid hormone mediated signaling pathway |
| odontogenesis |
| embryonic epithelial tube formation |
| mesoderm development |
| nephron development |
| embryonic limb morphogenesis |
| embryonic appendage morphogenesis |
| cardiac chamber morphogenesis |
| embryonic skeletal system development |
| kidney epithelium development |
| regulation of embryonic development |
| branching morphogenesis of an epithelial tube |
| epithelial tube formation |
| negative regulation of protein serine/threonine kinase activity |
| response to estradiol |
| vesicle |
| morphogenesis of embryonic epithelium |
| eye morphogenesis |
| tube formation |
| regulation of dendrite development |
| appendage morphogenesis |
| limb morphogenesis |
| hindbrain development |
| placenta development |
| mesenchymal cell differentiation |
| gastrulation |
| morphogenesis of a branching epithelium |
| neural tube development |
| negative regulation of DNA-binding transcription factor activity |
| regulation of reproductive process |
| cardiac muscle tissue development |
| protein localization to nucleus |
| growth factor activity |
| negative regulation of MAPK cascade |
| regulation of mitotic nuclear division |
| morphogenesis of a branching structure |
| cardiac chamber development |
| hormone-mediated signaling pathway |
| heparin binding |
| cartilage development |
| cytokine activity |
| regulation of reactive oxygen species metabolic process |
| appendage development |
| regulation of morphogenesis of an epithelium |
| limb development |
| cellular response to hypoxia |
| cellular response to steroid hormone stimulus |
| regulation of ossification |
| regulation of nuclear division |
| cellular response to decreased oxygen levels |
| transmembrane receptor protein serine/threonine kinase signaling pathway |
| response to nutrient |
| cellular response to oxygen levels |
| mesenchyme development |
| connective tissue development |
| negative regulation of neuron differentiation |
| negative regulation of protein kinase activity |
| regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| skeletal system morphogenesis |
| negative regulation of kinase activity |
| heart morphogenesis |
| positive regulation of cell-cell adhesion |
| sensory organ morphogenesis |
| regulation of animal organ morphogenesis |
| axon guidance |
| ossification |
| neuron projection guidance |
| kidney development |
| negative regulation of transferase activity |
| positive regulation of neuron projection development |
| renal system development |
| striated muscle tissue development |
| embryonic organ morphogenesis |
| negative regulation of neurogenesis |
| muscle tissue development |
| negative regulation of mitotic cell cycle |
| epithelial tube morphogenesis |
| negative regulation of nervous system development |
| camera-type eye development |
| urogenital system development |
| regulation of vasculature development |
| negative regulation of cell cycle process |
| response to steroid hormone |
| negative regulation of cell development |
| regulation of MAP kinase activity |
| response to hypoxia |
| response to decreased oxygen levels |
| eye development |
| visual system development |
| collagen-containing extracellular matrix |
| sensory system development |
| positive regulation of neuron differentiation |
| axonogenesis |
| negative regulation of organelle organization |
| in utero embryonic development |
| response to oxygen levels |
| positive regulation of cell projection organization |
| response to peptide hormone |
| regulation of cell-cell adhesion |
| positive regulation of cell adhesion |
| negative regulation of protein phosphorylation |
| axon development |
| gland development |
| reproductive structure development |
| regulation of DNA-binding transcription factor activity |
| reproductive system development |
| morphogenesis of an epithelium |
| cell morphogenesis involved in neuron differentiation |
| embryonic organ development |
| pattern specification process |
| negative regulation of phosphorylation |
| positive regulation of neurogenesis |
| response to peptide |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| skeletal system development |
| regulation of neuron projection development |
| response to nutrient levels |
| positive regulation of cell migration |
| cellular response to growth factor stimulus |
| cell-cell adhesion |
| negative regulation of intracellular signal transduction |
| cell part morphogenesis |
| regulation of protein serine/threonine kinase activity |
| cellular response to lipid |
| positive regulation of cellular component biogenesis |
| positive regulation of cell motility |
| heart development |
| response to growth factor |
| response to extracellular stimulus |
| positive regulation of nervous system development |
| positive regulation of cellular component movement |
| positive regulation of cell development |
| cellular response to organic cyclic compound |
| sensory organ development |
| chemotaxis |
| taxis |
| positive regulation of locomotion |
| cell population proliferation |
| cell morphogenesis involved in differentiation |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| tissue morphogenesis |
| embryonic morphogenesis |
| negative regulation of cell cycle |
| negative regulation of protein modification process |
| cellular response to hormone stimulus |
| regulation of mitotic cell cycle |
| chordate embryonic development |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| regulation of neuron differentiation |
| neuron projection development |
| developmental process involved in reproduction |
| negative regulation of cell population proliferation |
| regulation of cell adhesion |
| epithelial cell differentiation |
| regulation of plasma membrane bounded cell projection organization |
| positive regulation of cell death |
| negative regulation of cellular component organization |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| enzyme linked receptor protein signaling pathway |
| cell morphogenesis |
| protein localization to organelle |
| regulation of cellular response to stress |
| brain development |
| regulation of cell cycle process |
| regulation of MAPK cascade |
| head development |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| neuron development |
| regulation of neurogenesis |
| cellular component morphogenesis |
| tube development |
| regulation of cell migration |
| response to lipid |
| circulatory system development |
| regulation of kinase activity |
| negative regulation of apoptotic process |
| anatomical structure formation involved in morphogenesis |
| negative regulation of programmed cell death |
| response to hormone |
| regulation of cell motility |
| response to organic cyclic compound |
| regulation of nervous system development |
| cell adhesion |
| regulation of cell development |
| biological adhesion |
| negative regulation of developmental process |
| animal organ morphogenesis |
| regulation of cellular component biogenesis |
| positive regulation of cell differentiation |
| regulation of transferase activity |
| embryo development |
| central nervous system development |
| regulation of locomotion |
| regulation of cellular component movement |
| negative regulation of cell death |
| response to organonitrogen compound |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| negative regulation of cellular protein metabolic process |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| response to nitrogen compound |
| negative regulation of protein metabolic process |
| epithelium development |
| plasma membrane bounded cell projection organization |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of molecular function |
| response to abiotic stimulus |
| cell projection organization |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| regulation of organelle organization |
| locomotion |
| negative regulation of RNA metabolic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| reproductive process |
| reproduction |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| cellular protein localization |
| regulation of phosphorylation |
| extracellular space |
| cellular macromolecule localization |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| positive regulation of signal transduction |
| regulation of cell death |
| cellular response to stress |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 3497
- Expression level (log2 read counts): 2.59
Expression Distribution
BMP7 Expression in NALM6 Cells: 2.59
