BOP1 [The Human Chemical-Genetic Interaction Map Project]

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======= BOP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BOP1
  * **<color #00a2e8>Official Name</color>**: BOP1 ribosomal biogenesis factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23246|23246]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14137|Q14137]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BOP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BOP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610596|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. {ECO:0000255|HAMAP-Rule:MF_03027, ECO:0000269|PubMed:17353269, ECO:0000269|PubMed:24120868}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
|BOP1NT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|PeBoW complex|
|endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|endonucleolytic cleavage involved in rRNA processing|
|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|maturation of LSU-rRNA|
|cleavage involved in rRNA processing|
|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|preribosome, large subunit precursor|
|maturation of 5.8S rRNA|
|ribosomal large subunit assembly|
|ribonucleoprotein complex binding|
|ribosome assembly|
|ribosomal large subunit biogenesis|
|RNA phosphodiester bond hydrolysis, endonucleolytic|
|ribonucleoprotein complex|
|RNA phosphodiester bond hydrolysis|
|regulation of signal transduction by p53 class mediator|
|rRNA processing|
|rRNA metabolic process|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|nucleic acid phosphodiester bond hydrolysis|
|ribosome biogenesis|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|cell population proliferation|
|organelle assembly|
|cellular protein-containing complex assembly|
|nucleolus|
|RNA processing|
|regulation of cell cycle|
|RNA binding|
|protein-containing complex assembly|
|RNA metabolic process|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|-1.9|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.72|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|2.37|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 657/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|26/28|
|blood|21/28|
|bone|20/26|
|breast|23/33|
|central nervous system|52/56|
|cervix|3/4|
|colorectal|15/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|13/16|
|kidney|20/21|
|liver|19/20|
|lung|67/75|
|lymphocyte|14/16|
|ovary|23/26|
|pancreas|24/24|
|peripheral nervous system|14/16|
|plasma cell|13/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|25/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1382
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.07 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BOP1 Expression in NALM6 Cells: 7.07'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>