BOP1

Entrez Summary: N/A
UniProt Summary: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. {ECO:0000255|HAMAP-Rule:MF_03027, ECO:0000269|PubMed:17353269, ECO:0000269|PubMed:24120868}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 657/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	26/28
blood	21/28
bone	20/26
breast	23/33
central nervous system	52/56
cervix	3/4
colorectal	15/17
esophagus	13/13
fibroblast	1/1
gastric	13/16
kidney	20/21
liver	19/20
lung	67/75
lymphocyte	14/16
ovary	23/26
pancreas	24/24
peripheral nervous system	14/16
plasma cell	13/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	25/29
uterus	3/5

Expression Distribution

WD40
BOP1NT

cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
PeBoW complex
endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
endonucleolytic cleavage involved in rRNA processing
maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
maturation of LSU-rRNA
cleavage involved in rRNA processing
maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
preribosome, large subunit precursor
maturation of 5.8S rRNA
ribosomal large subunit assembly
ribonucleoprotein complex binding
ribosome assembly
ribosomal large subunit biogenesis
RNA phosphodiester bond hydrolysis, endonucleolytic
ribonucleoprotein complex
RNA phosphodiester bond hydrolysis
regulation of signal transduction by p53 class mediator
rRNA processing
rRNA metabolic process
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
nucleic acid phosphodiester bond hydrolysis
ribosome biogenesis
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
cell population proliferation
organelle assembly
cellular protein-containing complex assembly
nucleolus
RNA processing
regulation of cell cycle
RNA binding
protein-containing complex assembly
RNA metabolic process
regulation of intracellular signal transduction
protein-containing complex subunit organization
gene expression