BRD7 [The Human Chemical-Genetic Interaction Map Project]

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======= BRD7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BRD7
  * **<color #00a2e8>Official Name</color>**: bromodomain containing 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29117|29117]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NPI1|Q9NPI1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BRD7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BRD7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618489|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein which is a member of the bromodomain-containing protein family. The product of this gene has been identified as a component of one form of the SWI/SNF chromatin remodeling complex, and as a protein which interacts with p53 and is required for p53-dependent oncogene-induced senescence which prevents tumor growth. Pseudogenes have been described on chromosomes 2, 3, 6, 13 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase. {ECO:0000250, ECO:0000269|PubMed:16265664, ECO:0000269|PubMed:16475162, ECO:0000269|PubMed:20215511, ECO:0000269|PubMed:20228809, ECO:0000269|PubMed:20660729}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF3512|
|Bromodomain|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|lysine-acetylated histone binding|
|positive regulation of histone acetylation|
|positive regulation of peptidyl-lysine acetylation|
|positive regulation of protein acetylation|
|regulation of histone acetylation|
|regulation of peptidyl-lysine acetylation|
|p53 binding|
|regulation of protein acetylation|
|positive regulation of histone modification|
|negative regulation of G1/S transition of mitotic cell cycle|
|positive regulation of chromatin organization|
|negative regulation of cell cycle G1/S phase transition|
|histone binding|
|regulation of histone modification|
|regulation of G1/S transition of mitotic cell cycle|
|regulation of cell cycle G1/S phase transition|
|positive regulation of chromosome organization|
|regulation of signal transduction by p53 class mediator|
|regulation of chromatin organization|
|negative regulation of mitotic cell cycle phase transition|
|transcription regulatory region DNA binding|
|negative regulation of cell cycle phase transition|
|transcription corepressor activity|
|transcription coactivator activity|
|negative regulation of mitotic cell cycle|
|negative regulation of cell cycle process|
|transcription factor binding|
|regulation of chromosome organization|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|regulation of mitotic cell cycle phase transition|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of cell cycle phase transition|
|negative regulation of cell cycle|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|negative regulation of cell population proliferation|
|regulation of cell cycle process|
|cell-cell signaling|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-2.51|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-2.39|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-2.18|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-2.15|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-2.13|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-2.11|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-2.1|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-1.92|
|[[:results:exp11|CCCP 1μM R00 exp11]]|1.74|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.77|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.78|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|1.88|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|1.95|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|2.26|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pbrm1|PBRM1]]|0.59|
|[[:human genes:p:polr2j3|POLR2J3]]|0.418|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17513
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.04 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BRD7 Expression in NALM6 Cells: 7.04'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>