BRD7

Gene Information

Official Symbol: BRD7
Official Name: bromodomain containing 7
Aliases and Previous Symbols: N/A
Entrez ID: 29117
UniProt: Q9NPI1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a protein which is a member of the bromodomain-containing protein family. The product of this gene has been identified as a component of one form of the SWI/SNF chromatin remodeling complex, and as a protein which interacts with p53 and is required for p53-dependent oncogene-induced senescence which prevents tumor growth. Pseudogenes have been described on chromosomes 2, 3, 6, 13 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010].
UniProt Summary: Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase. {ECO:0000250, ECO:0000269|PubMed:16265664, ECO:0000269|PubMed:16475162, ECO:0000269|PubMed:20215511, ECO:0000269|PubMed:20228809, ECO:0000269|PubMed:20660729}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-2.51
MLN-4924 0.2μM R00 exp21	-2.39
THZ531 0.11 to 0.125μM on day4 R07 exp410	-2.18
BI-6727 0.0125μM R03 exp97	-2.15
THZ531 0.11μM R07 exp409	-2.13
THZ531 0.11 to 0.175μM on day4 R07 exp413	-2.11
iCRT14 30μM R08 exp492	-2.1
Tubacin 1.6μM R07 exp416	-1.92
CCCP 1μM R00 exp11	1.74
UMK57 1μM R01 exp59	1.77
Chloramphenicol 2μM R00 exp12	1.78
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	1.88
UM0131023 0.05μM R05 exp248	1.95
Hypoxia 5%O2 R04 exp191	2.26

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17513
Expression level (log2 read counts): 7.04

Expression Distribution

Gene	Correlation
PBRM1	0.59
POLR2J3	0.418

DUF3512
Bromodomain

lysine-acetylated histone binding
positive regulation of histone acetylation
positive regulation of peptidyl-lysine acetylation
positive regulation of protein acetylation
regulation of histone acetylation
regulation of peptidyl-lysine acetylation
p53 binding
regulation of protein acetylation
positive regulation of histone modification
negative regulation of G1/S transition of mitotic cell cycle
positive regulation of chromatin organization
negative regulation of cell cycle G1/S phase transition
histone binding
regulation of histone modification
regulation of G1/S transition of mitotic cell cycle
regulation of cell cycle G1/S phase transition
positive regulation of chromosome organization
regulation of signal transduction by p53 class mediator
regulation of chromatin organization
negative regulation of mitotic cell cycle phase transition
transcription regulatory region DNA binding
negative regulation of cell cycle phase transition
transcription corepressor activity
transcription coactivator activity
negative regulation of mitotic cell cycle
negative regulation of cell cycle process
transcription factor binding
regulation of chromosome organization
Wnt signaling pathway
cell-cell signaling by wnt
regulation of mitotic cell cycle phase transition
cell surface receptor signaling pathway involved in cell-cell signaling
regulation of cell cycle phase transition
negative regulation of cell cycle
positive regulation of organelle organization
regulation of mitotic cell cycle
negative regulation of cell population proliferation
regulation of cell cycle process
cell-cell signaling
regulation of cell cycle