BRF1

Gene Information

Official Symbol: BRF1
Official Name: BRF1 RNA polymerase III transcription initiation factor subunit
Aliases and Previous Symbols: N/A
Entrez ID: 2972
UniProt: Q92994
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes one of the three subunits of the RNA polymerase III transcription factor complex. This complex plays a central role in transcription initiation by RNA polymerase III on genes encoding tRNA, 5S rRNA, and other small structural RNAs. The gene product belongs to the TF2B family. Several alternatively spliced variants encoding different isoforms, that function at different promoters transcribed by RNA polymerase III, have been identified. [provided by RefSeq, Jun 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 377/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	13/28
blood	18/28
bone	12/25
breast	14/33
central nervous system	28/56
cervix	1/4
colorectal	11/17
esophagus	4/13
fibroblast	0/1
gastric	9/15
kidney	15/21
liver	11/20
lung	32/75
lymphocyte	9/14
ovary	13/26
pancreas	9/24
peripheral nervous system	7/16
plasma cell	11/15
prostate	0/1
skin	14/24
soft tissue	3/7
thyroid	1/2
upper aerodigestive	9/22
urinary tract	17/29
uterus	4/5

Essentiality in NALM6

Essentiality Rank: 2308
Expression level (log2 read counts): 6.37

Expression Distribution

Screen	Score
Hippuristanol 0.12μM R08 exp488	-1.71
Actinomycin-D 0.001μM R00 exp3	2.06

BRF1
TFIIB
TF Zn Ribbon

RNA polymerase III type 3 promoter sequence-specific DNA binding
transcription factor TFIIIB complex
RNA polymerase III preinitiation complex assembly
tRNA transcription
positive regulation of transcription by RNA polymerase III
transcription initiation from RNA polymerase III promoter
rRNA transcription
TBP-class protein binding
regulation of transcription by RNA polymerase III
transcription preinitiation complex assembly
transcription by RNA polymerase III
ncRNA transcription
protein-DNA complex assembly
DNA-templated transcription, initiation
protein-DNA complex subunit organization
transcription factor binding
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
cellular protein-containing complex assembly
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
positive regulation of transcription, DNA-templated
protein-containing complex assembly
cellular nitrogen compound biosynthetic process
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
positive regulation of RNA metabolic process
macromolecule biosynthetic process
protein-containing complex subunit organization
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
gene expression
positive regulation of biosynthetic process