BRK1

Gene Information

Official Symbol: BRK1
Official Name: BRICK1 subunit of SCAR/WAVE actin nucleating complex
Aliases and Previous Symbols: N/A
Entrez ID: 55845
UniProt: Q8WUW1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex. As component of the WAVE1 complex, required for BDNF- NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). {ECO:0000250|UniProtKB:Q91VR8, ECO:0000269|PubMed:18560548}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 24/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	6/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	3/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	1/20
lung	1/75
lymphocyte	1/16
ovary	0/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17864
Expression level (log2 read counts): 6.18

Expression Distribution

Screen	Score
SNS-032 15μM R08 exp443	-1.88
GSK343 3μM R03 exp124	-1.85
LB-100 4.1μM R02 exp72	1.86
Docetaxel 0.002μM R01 exp45	1.95

positive regulation of Arp2/3 complex-mediated actin nucleation
SCAR complex
positive regulation of actin nucleation
regulation of Arp2/3 complex-mediated actin nucleation
positive regulation of lamellipodium assembly
Rac protein signal transduction
regulation of actin nucleation
positive regulation of lamellipodium organization
regulation of lamellipodium assembly
protein homotrimerization
regulation of lamellipodium organization
Rac GTPase binding
protein trimerization
vascular endothelial growth factor receptor signaling pathway
positive regulation of actin filament polymerization
positive regulation of plasma membrane bounded cell projection assembly
positive regulation of protein polymerization
immune response-regulating cell surface receptor signaling pathway involved in phagocytosis
Fc-gamma receptor signaling pathway involved in phagocytosis
Fc receptor mediated stimulatory signaling pathway
Fc-gamma receptor signaling pathway
regulation of actin filament polymerization
lamellipodium
regulation of actin polymerization or depolymerization
regulation of actin filament length
positive regulation of supramolecular fiber organization
regulation of plasma membrane bounded cell projection assembly
regulation of cell projection assembly
positive regulation of cytoskeleton organization
regulation of protein polymerization
actin filament organization
Fc receptor signaling pathway
Ras protein signal transduction
positive regulation of protein complex assembly
regulation of actin filament organization
protein-containing complex binding
small GTPase mediated signal transduction
phagocytosis
protein homooligomerization
regulation of actin cytoskeleton organization