BRSK2

Gene Information

Official Symbol: BRSK2
Official Name: BR serine/threonine kinase 2
Aliases and Previous Symbols: N/A
Entrez ID: 9024
UniProt: Q8IWQ3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress. {ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:20026642, ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:22669945, ECO:0000269|PubMed:22798068, ECO:0000269|PubMed:23029325}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8689
Expression level (log2 read counts): -2.6

Expression Distribution

Pkinase Tyr
Pkinase

ATPase regulator activity
microtubule cytoskeleton organization involved in establishment of planar polarity
distal axon
regulation of synaptic vesicle clustering
regulation of retrograde protein transport, ER to cytosol
tau-protein kinase activity
establishment of planar polarity
establishment of tissue polarity
regulation of protein exit from endoplasmic reticulum
regulation of ERAD pathway
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
morphogenesis of a polarized epithelium
tau protein binding
regulation of insulin secretion involved in cellular response to glucose stimulus
actin cytoskeleton reorganization
ATPase binding
regulation of ATPase activity
regulation of response to endoplasmic reticulum stress
ERAD pathway
regulation of synaptic vesicle cycle
establishment of cell polarity
G2/M transition of mitotic cell cycle
cell cycle G2/M phase transition
intrinsic apoptotic signaling pathway
peptidyl-serine phosphorylation
regulation of insulin secretion
regulation of proteasomal protein catabolic process
regulation of axonogenesis
establishment or maintenance of cell polarity
peptidyl-serine modification
regulation of peptide hormone secretion
magnesium ion binding
regulation of proteolysis involved in cellular protein catabolic process
regulation of intracellular protein transport
regulation of cellular protein catabolic process
response to endoplasmic reticulum stress
regulation of hormone secretion
mitotic cell cycle phase transition
cell cycle phase transition
apoptotic signaling pathway