BTBD18

Entrez Summary: N/A
UniProt Summary: Specifically required during spermatogenesis to promote expression of piRNA precursors. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity. Acts by facilitating transcription elongation at piRNA loci during pachytene. {ECO:0000250|UniProtKB:A0A0A6YY25}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
RUVBL2	0.558
POLR2J3	0.428

piRNA biosynthetic process
positive regulation of transcription elongation from RNA polymerase II promoter
piRNA metabolic process
regulation of transposition
negative regulation of transposition
male meiosis I
regulation of transcription elongation from RNA polymerase II promoter
positive regulation of DNA-templated transcription, elongation
male meiotic nuclear division
regulation of DNA-templated transcription, elongation
meiosis I
meiosis I cell cycle process
meiotic nuclear division
meiotic cell cycle process
meiotic cell cycle
nuclear division
organelle fission
cellular process involved in reproduction in multicellular organism
ncRNA metabolic process
spermatogenesis
male gamete generation
gamete generation
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
multi-organism reproductive process
cell cycle process
positive regulation of transcription by RNA polymerase II
cell cycle
reproductive process
reproduction
positive regulation of transcription, DNA-templated
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
RNA metabolic process
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression