C11orf80

Gene Information
  • Official Symbol: C11orf80
  • Official Name: chromosome 11 open reading frame 80
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 79703
  • UniProt: Q8N6T0
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: N/A
Function Summary
  • Entrez Summary: N/A
  • UniProt Summary: Isoform 3: Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. {ECO:0000250|UniProtKB:J3QMY9}.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 11887
  • Expression level (log2 read counts): 4.05

Expression Distribution

  • Last modified: 2025/12/10 20:19
  • by 127.0.0.1