C12orf39 [The Human Chemical-Genetic Interaction Map Project]

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======= C12orf39 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SPX
  * **<color #00a2e8>Official Name</color>**: spexin hormone
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80763|80763]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BT56|Q9BT56]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C12orf39&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C12orf39|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619246|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role as a central modulator of cardiovascular and renal function and nociception. Plays also a role in energy metabolism and storage. Inhibits adrenocortical cell proliferation with minor stimulation on corticosteroid release (By similarity). {ECO:0000250}. Spexin-2: Intracerebroventricular administration of the peptide induces a decrease in heart rate, but no change in arterial pressure, and an increase in urine flow rate. Intraventricular administration of the peptide induces antinociceptive activity (By similarity). {ECO:0000250}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of renal sodium excretion|
|positive regulation of gastro-intestinal system smooth muscle contraction|
|regulation of gastro-intestinal system smooth muscle contraction|
|long-chain fatty acid import into cell|
|lipid import into cell|
|negative regulation of heart rate|
|negative regulation of appetite|
|negative regulation of response to food|
|positive regulation of systemic arterial blood pressure|
|dense core granule|
|negative regulation of response to extracellular stimulus|
|negative regulation of response to nutrient levels|
|regulation of response to food|
|regulation of renal sodium excretion|
|regulation of appetite|
|regulation of excretion|
|negative regulation of heart contraction|
|regulation of response to extracellular stimulus|
|regulation of response to nutrient levels|
|neuropeptide hormone activity|
|positive regulation of smooth muscle contraction|
|negative regulation of blood circulation|
|regulation of renal system process|
|positive regulation of blood pressure|
|regulation of sensory perception of pain|
|regulation of sensory perception|
|positive regulation of muscle contraction|
|long-chain fatty acid transport|
|regulation of smooth muscle contraction|
|fatty acid transport|
|transport vesicle|
|regulation of systemic arterial blood pressure|
|regulation of heart rate|
|regulation of nervous system process|
|monocarboxylic acid transport|
|regulation of muscle contraction|
|regulation of blood pressure|
|negative regulation of secretion|
|regulation of muscle system process|
|regulation of heart contraction|
|regulation of blood circulation|
|carboxylic acid transport|
|organic acid transport|
|lipid transport|
|lipid localization|
|negative regulation of response to external stimulus|
|blood circulation|
|circulatory system process|
|organic anion transport|
|negative regulation of transport|
|response to nutrient levels|
|response to extracellular stimulus|
|anion transport|
|regulation of system process|
|import into cell|
|regulation of secretion|
|regulation of response to external stimulus|
|negative regulation of multicellular organismal process|
|ion transport|
|extracellular space|
|negative regulation of response to stimulus|
|positive regulation of multicellular organismal process|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|-1.7|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16422
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C12ORF39 Expression in NALM6 Cells: -4.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>