C12orf39

Entrez Summary: N/A
UniProt Summary: Plays a role as a central modulator of cardiovascular and renal function and nociception. Plays also a role in energy metabolism and storage. Inhibits adrenocortical cell proliferation with minor stimulation on corticosteroid release (By similarity). {ECO:0000250}. Spexin-2: Intracerebroventricular administration of the peptide induces a decrease in heart rate, but no change in arterial pressure, and an increase in urine flow rate. Intraventricular administration of the peptide induces antinociceptive activity (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
BI-6727 0.001μM R01 exp42	-1.7
Myriocin 25μM R06 exp293	1.86

negative regulation of renal sodium excretion
positive regulation of gastro-intestinal system smooth muscle contraction
regulation of gastro-intestinal system smooth muscle contraction
long-chain fatty acid import into cell
lipid import into cell
negative regulation of heart rate
negative regulation of appetite
negative regulation of response to food
positive regulation of systemic arterial blood pressure
dense core granule
negative regulation of response to extracellular stimulus
negative regulation of response to nutrient levels
regulation of response to food
regulation of renal sodium excretion
regulation of appetite
regulation of excretion
negative regulation of heart contraction
regulation of response to extracellular stimulus
regulation of response to nutrient levels
neuropeptide hormone activity
positive regulation of smooth muscle contraction
negative regulation of blood circulation
regulation of renal system process
positive regulation of blood pressure
regulation of sensory perception of pain
regulation of sensory perception
positive regulation of muscle contraction
long-chain fatty acid transport
regulation of smooth muscle contraction
fatty acid transport
transport vesicle
regulation of systemic arterial blood pressure
regulation of heart rate
regulation of nervous system process
monocarboxylic acid transport
regulation of muscle contraction
regulation of blood pressure
negative regulation of secretion
regulation of muscle system process
regulation of heart contraction