C12orf57

Entrez Summary: This gene is ubiquitously expressed in human tissues. It is required for development of the human corpus callosum. Mutations in this gene are associated with Temtamy syndrome (TEMTYS). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014].
UniProt Summary: In brain, may be required for corpus callusum development. {ECO:0000269|PubMed:23453666}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

third ventricle development
psychomotor behavior
corpus callosum morphogenesis
motor behavior
regulation of skeletal muscle contraction
corpus callosum development
central nervous system projection neuron axonogenesis
ventricular system development
central nervous system neuron axonogenesis
central nervous system neuron development
post-embryonic development
regulation of striated muscle contraction
camera-type eye morphogenesis
eye morphogenesis
regulation of muscle contraction
central nervous system neuron differentiation
regulation of muscle system process
sensory organ morphogenesis
telencephalon development
cognition
camera-type eye development
eye development
visual system development
sensory system development
axonogenesis
forebrain development
nuclear speck
axon development
cell morphogenesis involved in neuron differentiation
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
cell part morphogenesis
sensory organ development
cell morphogenesis involved in differentiation
behavior
regulation of system process
neuron projection development
cell morphogenesis
brain development