C15orf38

Gene Information

Official Symbol: ARPIN
Official Name: actin related protein 2/3 complex inhibitor
Aliases and Previous Symbols: N/A
Entrez ID: 348110
UniProt: Q7Z6K5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Regulates actin polymerization by inhibiting the actin- nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence. {ECO:0000269|PubMed:24132237}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12434
Expression level (log2 read counts): 3.53

Expression Distribution

Screen	Score
Tubacin 1.6μM R07 exp416	-1.7
Demecolcine 0.03μM R05 exp228	1.97

negative regulation of lamellipodium morphogenesis
directional locomotion
negative regulation of lamellipodium organization
negative regulation of actin nucleation
regulation of lamellipodium morphogenesis
regulation of actin nucleation
regulation of lamellipodium organization
negative regulation of supramolecular fiber organization
negative regulation of cytoskeleton organization
regulation of actin filament polymerization
lamellipodium
negative regulation of cell projection organization
regulation of actin polymerization or depolymerization
regulation of actin filament length
regulation of protein polymerization
negative regulation of cell migration
regulation of actin filament organization
negative regulation of cell motility
negative regulation of cellular component movement
negative regulation of locomotion
regulation of actin cytoskeleton organization
regulation of supramolecular fiber organization
negative regulation of organelle organization
regulation of cellular component size
regulation of actin filament-based process
regulation of protein complex assembly
regulation of cell morphogenesis
regulation of anatomical structure size
regulation of cytoskeleton organization
regulation of plasma membrane bounded cell projection organization
negative regulation of cellular component organization
regulation of cell projection organization
regulation of cell migration
regulation of cell motility
negative regulation of developmental process
regulation of cellular component biogenesis
regulation of locomotion
regulation of cellular component movement
regulation of anatomical structure morphogenesis
regulation of organelle organization