C15orf60

Gene Information
  • Official Symbol: REC114
  • Official Name: REC114 meiotic recombination protein
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 283677
  • UniProt: Q7Z4M0
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: N/A
  • UniProt Summary: Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with IHO1/CCDC36 and MEI4, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. {ECO:0000250|UniProtKB:Q9CWH4}.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 7871
  • Expression level (log2 read counts): -2.56

Expression Distribution

  • Last modified: 2026/01/07 22:36
  • by 127.0.0.1