C16orf47

Gene Information

Official Symbol: ZFHX3
Official Name: zinc finger homeobox 3
Aliases and Previous Symbols: N/A
Entrez ID: 463
UniProt: Q15911
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the cell cycle inhibitor cyclin-dependent kinase inhibitor 1A (also known as p21CIP1). This gene is reported to function as a tumor suppressor in several cancers, and sequence variants of this gene are also associated with atrial fibrillation. Multiple transcript variants expressed from alternate promoters and encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
UniProt Summary: Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD- dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down- regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, upregulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010). {ECO:0000250|UniProtKB:Q61329, ECO:0000269|PubMed:11312261, ECO:0000269|PubMed:17330845, ECO:0000269|PubMed:20599712, ECO:0000269|PubMed:20720010, ECO:0000269|PubMed:25105025}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16036
Expression level (log2 read counts): -3.59

Expression Distribution

Screen	Score
MS023 7μM R03 exp135	-1.87
S-DABN 8μM R03 exp112	-1.87
L-BMAA 500 to 750μM on day4 R04 exp185	1.93

regulation of locomotor rhythm
circadian regulation of gene expression
regulation of behavior
regulation of circadian rhythm
circadian rhythm
cell cycle arrest
response to transforming growth factor beta
transcription factor complex
transcription regulatory region DNA binding
DNA-binding transcription repressor activity, RNA polymerase II-specific
rhythmic process
nuclear body
muscle organ development
enzyme binding
positive regulation of cell adhesion
muscle structure development
transcription by RNA polymerase II
RNA polymerase II proximal promoter sequence-specific DNA binding
response to growth factor
negative regulation of cell cycle
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
regulation of neuron differentiation
DNA-binding transcription factor activity
regulation of cell adhesion
brain development
head development
regulation of neurogenesis
zinc ion binding
negative regulation of transcription by RNA polymerase II
regulation of nervous system development
regulation of cell development
central nervous system development
cell cycle process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
regulation of cell cycle
negative regulation of transcription, DNA-templated