C19orf26

Gene Information

Official Symbol: CBARP
Official Name: CACN subunit beta associated regulatory protein
Aliases and Previous Symbols: N/A
Entrez ID: 255057
UniProt: Q8N350
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: N/A

Function Summary

Entrez Summary: N/A
UniProt Summary: Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis. {ECO:0000250|UniProtKB:Q66L44}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9092
Expression level (log2 read counts): -0.05

Expression Distribution

negative regulation of calcium ion-dependent exocytosis
negative regulation of voltage-gated calcium channel activity
negative regulation of regulated secretory pathway
negative regulation of exocytosis
regulation of voltage-gated calcium channel activity
negative regulation of calcium ion transmembrane transporter activity
negative regulation of calcium ion transmembrane transport
negative regulation of cation channel activity
regulation of calcium ion-dependent exocytosis
negative regulation of calcium ion transport
synaptic vesicle membrane
negative regulation of ion transmembrane transporter activity
negative regulation of transporter activity
negative regulation of cation transmembrane transport
secretory granule
regulation of calcium ion transmembrane transporter activity
negative regulation of ion transmembrane transport
negative regulation of transmembrane transport
ion channel binding
growth cone
regulation of calcium ion transmembrane transport
negative regulation of ion transport
regulation of regulated secretory pathway
regulation of cation channel activity
negative regulation of secretion by cell
regulation of exocytosis
negative regulation of secretion
regulation of calcium ion transport
regulation of ion transmembrane transporter activity
regulation of transmembrane transporter activity
regulation of transporter activity
regulation of cation transmembrane transport
regulation of metal ion transport
regulation of ion transmembrane transport
negative regulation of transport
cell junction
regulation of vesicle-mediated transport
regulation of transmembrane transport
regulation of ion transport
regulation of secretion by cell