C1orf168

Entrez Summary: N/A
UniProt Summary: Adapter protein that plays a role in T-cell receptor (TCR)-mediated activation of signaling pathways. Required for T- cell activation and integrin-mediated T-cell adhesion in response to TCR stimulation (PubMed:27335501). {ECO:0000269|PubMed:27335501}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cell adhesion mediated by integrin
immunological synapse
integrin-mediated signaling pathway
T cell receptor signaling pathway
protein localization to plasma membrane
membrane raft
protein localization to cell periphery
antigen receptor-mediated signaling pathway
immune response-activating cell surface receptor signaling pathway
protein localization to membrane
immune response-regulating cell surface receptor signaling pathway
immune response-activating signal transduction
immune response-regulating signaling pathway
activation of immune response
positive regulation of immune response
cell adhesion
biological adhesion
regulation of immune response
positive regulation of immune system process
cellular protein localization
cellular macromolecule localization
regulation of immune system process