C1QTNF3 [The Human Chemical-Genetic Interaction Map Project]

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======= C1QTNF3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: C1QTNF3
  * **<color #00a2e8>Official Name</color>**: C1q and TNF related 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=114899|114899]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BXJ4|Q9BXJ4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C1QTNF3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C1QTNF3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612045|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C1q|
|Collagen|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of adiponectin secretion|
|regulation of adiponectin secretion|
|negative regulation of monocyte chemotactic protein-1 production|
|cellular triglyceride homeostasis|
|negative regulation of interleukin-6 secretion|
|regulation of monocyte chemotactic protein-1 production|
|negative regulation of gluconeogenesis|
|negative regulation of chemokine production|
|negative regulation of NIK/NF-kappaB signaling|
|acylglycerol homeostasis|
|triglyceride homeostasis|
|negative regulation of cellular carbohydrate metabolic process|
|negative regulation of interleukin-6 production|
|regulation of endocrine process|
|regulation of gluconeogenesis|
|negative regulation of carbohydrate metabolic process|
|protein trimerization|
|collagen trimer|
|negative regulation of cytokine secretion|
|regulation of chemokine production|
|cell|
|negative regulation of small molecule metabolic process|
|regulation of carbohydrate biosynthetic process|
|fat cell differentiation|
|regulation of NIK/NF-kappaB signaling|
|regulation of glucose metabolic process|
|positive regulation of hormone secretion|
|negative regulation of protein secretion|
|lipid homeostasis|
|negative regulation of inflammatory response|
|positive regulation of cytokine secretion|
|regulation of cellular carbohydrate metabolic process|
|negative regulation of peptide secretion|
|regulation of interleukin-6 production|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|regulation of carbohydrate metabolic process|
|negative regulation of defense response|
|negative regulation of secretion|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|negative regulation of cytokine production|
|positive regulation of peptide secretion|
|regulation of inflammatory response|
|negative regulation of response to external stimulus|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|regulation of small molecule metabolic process|
|positive regulation of secretion|
|positive regulation of cytokine production|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|negative regulation of transport|
|regulation of peptide secretion|
|negative regulation of intracellular signal transduction|
|protein complex oligomerization|
|regulation of hormone levels|
|regulation of system process|
|regulation of cytokine production|
|regulation of protein transport|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|molecular function|
|regulation of defense response|
|regulation of secretion|
|cellular homeostasis|
|positive regulation of transport|
|regulation of protein localization|
|regulation of response to external stimulus|
|chemical homeostasis|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|negative regulation of response to stimulus|
|homeostatic process|
|positive regulation of multicellular organismal process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-2.06|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|2.15|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|2.27|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16603
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C1QTNF3 Expression in NALM6 Cells: 2.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>