C1QTNF4

Gene Information

Official Symbol: C1QTNF4
Official Name: C1q and TNF related 4
Aliases and Previous Symbols: N/A
Entrez ID: 114900
UniProt: Q9BXJ3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: May act as a pro-inflammatory cytokine, that induces the activation of NF-kappa-B signaling pathway and up-regulates IL6 production. {ECO:0000269|PubMed:21658842}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 8/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	2/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 11664
Expression level (log2 read counts): -2.38

Expression Distribution

positive regulation of interleukin-6-mediated signaling pathway
regulation of interleukin-6-mediated signaling pathway
positive regulation of tumor necrosis factor secretion
regulation of tumor necrosis factor secretion
positive regulation of interleukin-6 secretion
positive regulation of cytokine-mediated signaling pathway
positive regulation of response to cytokine stimulus
positive regulation of NIK/NF-kappaB signaling
positive regulation of tumor necrosis factor production
positive regulation of tumor necrosis factor superfamily cytokine production
positive regulation of interleukin-6 production
regulation of NIK/NF-kappaB signaling
positive regulation of cytokine secretion
regulation of interleukin-6 production
regulation of tumor necrosis factor production
regulation of tumor necrosis factor superfamily cytokine production
regulation of cytokine-mediated signaling pathway
cytokine activity
regulation of response to cytokine stimulus
regulation of cytokine secretion
positive regulation of protein secretion
positive regulation of peptide secretion
positive regulation of secretion by cell
positive regulation of protein transport
positive regulation of secretion
positive regulation of cytokine production
positive regulation of establishment of protein localization
regulation of protein secretion
regulation of peptide secretion
regulation of cytokine production
regulation of protein transport
regulation of peptide transport
regulation of establishment of protein localization
regulation of secretion by cell
molecular function
regulation of secretion
positive regulation of transport
positive regulation of intracellular signal transduction
regulation of protein localization
extracellular space