C1R

Entrez Summary: N/A
UniProt Summary: C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Expression Distribution

Screen	Score
Pifithrin-alpha 20μM R07 exp390	1.7
GSK-J4 1-1.25μM to day4 R07 exp363	1.98

EGF CA
CUB

zymogen activation
serine-type peptidase activity
regulation of complement activation
regulation of humoral immune response
blood microparticle
protein processing
complement activation, classical pathway
serine-type endopeptidase activity
humoral immune response mediated by circulating immunoglobulin
complement activation
immunoglobulin mediated immune response
B cell mediated immunity
protein maturation
lymphocyte mediated immunity
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
humoral immune response
regulation of immune effector process
adaptive immune response
activation of immune response
calcium ion binding
innate immune response
leukocyte mediated immunity
positive regulation of immune response
defense response to other organism
immune effector process
regulation of immune response
positive regulation of immune system process
proteolysis
response to other organism
response to external biotic stimulus
response to biotic stimulus
defense response
extracellular space
regulation of immune system process
immune response
extracellular region
gene expression