C4orf27

Entrez Summary: N/A
UniProt Summary: Acts as a cofactor for serine ADP-ribosylation by conferring serine specificity on PARP1 and PARP2: interacts with PARP1 and PARP1 and is able to change amino acid specificity toward serine (PubMed:28190768). Promotes histone serine ADP- ribosylation in response to DNA damage, limiting DNA damage- induced PARP1 hyper-automodification, and ensuring genome stability (PubMed:27067600, PubMed:28190768). {ECO:0000269|PubMed:27067600, ECO:0000269|PubMed:28190768}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Rucaparib 6.5μM R08 exp520	-3.11
Olaparib 4μM R08 exp512	-2.21

poly-ADP-D-ribose binding
peptidyl-serine ADP-ribosylation
regulation of protein ADP-ribosylation
protein ADP-ribosylation
histone binding
peptidyl-serine modification
cellular response to DNA damage stimulus
zinc ion binding
peptidyl-amino acid modification
cellular response to stress
regulation of protein modification process