C9orf3 [The Human Chemical-Genetic Interaction Map Project]

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======= C9orf3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AOPEP
  * **<color #00a2e8>Official Name</color>**: aminopeptidase O (putative)
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84909|84909]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N6M6|Q8N6M6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C9orf3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C9orf3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619600|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Aminopeptidases catalyze the hydrolysis of amino acid residues from the N-terminus of peptide or protein substrates. Able to cleave angiotensin III to generate angiotensin IV, a bioactive peptide of the renin-angiotensin pathway. Not able to cleave angiotensin I and angiotensin II. May play a role in the proteolytic processing of bioactive peptides in tissues such as testis and heart. {ECO:0000269|PubMed:15687497}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Leuk-A4-hydro C|
|Peptidase M1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of angiotensin levels in blood|
|angiotensin maturation|
|regulation of systemic arterial blood pressure by circulatory renin-angiotensin|
|metalloaminopeptidase activity|
|regulation of systemic arterial blood pressure by renin-angiotensin|
|aminopeptidase activity|
|peptide hormone processing|
|regulation of systemic arterial blood pressure by hormone|
|regulation of systemic arterial blood pressure mediated by a chemical signal|
|endocrine process|
|metallopeptidase activity|
|regulation of systemic arterial blood pressure|
|protein processing|
|regulation of blood pressure|
|hormone metabolic process|
|protein maturation|
|blood circulation|
|circulatory system process|
|peptide metabolic process|
|regulation of hormone levels|
|cellular amide metabolic process|
|zinc ion binding|
|nucleolus|
|proteolysis|
|system process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|1.74|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|2.2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16850
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C9ORF3 Expression in NALM6 Cells: 3.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>