CABYR [The Human Chemical-Genetic Interaction Map Project]

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======= CABYR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CABYR
  * **<color #00a2e8>Official Name</color>**: calcium binding tyrosine phosphorylation regulated
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26256|26256]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75952|O75952]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CABYR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CABYR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612135|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction. Isoform 1 binds calcium in vitro. Isoform 2 and isoform 6 probably bind calcium. Isoform 3 and isoform 5 do not bind calcium in vitro. Isoform 4 probably does not bind calcium.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RIIa|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sperm fibrous sheath|
|epithelial cilium movement involved in extracellular fluid movement|
|sperm capacitation|
|extracellular transport|
|cilium movement|
|motile cilium|
|SH3 domain binding|
|spermatid development|
|spermatid differentiation|
|cell maturation|
|microtubule-based transport|
|developmental maturation|
|germ cell development|
|microtubule-based movement|
|cellular process involved in reproduction in multicellular organism|
|cytoskeleton|
|protein heterodimerization activity|
|spermatogenesis|
|male gamete generation|
|developmental process involved in reproduction|
|microtubule-based process|
|gamete generation|
|calcium ion binding|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|multi-organism reproductive process|
|reproductive process|
|reproduction|
|movement of cell or subcellular component|
|cell development|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-1.87|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|-1.86|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-1.74|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.75|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|2.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12334
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.5 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CABYR Expression in NALM6 Cells: 1.5'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>