CABYR

Entrez Summary: N/A
UniProt Summary: May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction. Isoform 1 binds calcium in vitro. Isoform 2 and isoform 6 probably bind calcium. Isoform 3 and isoform 5 do not bind calcium in vitro. Isoform 4 probably does not bind calcium.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Taxol 0.004μM R03 exp103	-1.87
RO-3307 4.7μM R02 exp80	-1.86
Methotrexate 0.01μM R08 exp501	-1.74
Dorsomorphin 5μM R07 exp357	1.75
Dimethyloxaloylglycine 100μM R05 exp229	2.03

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

sperm fibrous sheath
epithelial cilium movement involved in extracellular fluid movement
sperm capacitation
extracellular transport
cilium movement
motile cilium
SH3 domain binding
spermatid development
spermatid differentiation
cell maturation
microtubule-based transport
developmental maturation
germ cell development
microtubule-based movement
cellular process involved in reproduction in multicellular organism
cytoskeleton
protein heterodimerization activity
spermatogenesis
male gamete generation
developmental process involved in reproduction
microtubule-based process
gamete generation
calcium ion binding
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
multi-organism reproductive process
reproductive process
reproduction
movement of cell or subcellular component
cell development
extracellular region