CACNA1D

Gene Information

Official Symbol: CACNA1D
Official Name: calcium voltage-gated channel subunit alpha1 D
Aliases and Previous Symbols: N/A
Entrez ID: 776
UniProt: Q01668
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012].
UniProt Summary: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). {ECO:0000269|PubMed:18482979, ECO:0000269|PubMed:25620733, ECO:0000269|PubMed:28472301}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
TIC10 10μM R08 exp532	-2.26
UNC1999 2μM R03 exp155	-1.93
Nifuroxazide 5μM R03 exp102	-1.71
Thimerosal 0.85μM R08 exp529	1.7
Dimethyloxaloylglycine 11μM R07 exp314	1.78
Nicotinamide 2000μM R01 exp50	1.83

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12530
Expression level (log2 read counts): 1.94

Expression Distribution

Ca chan IQ
Ion trans
PKD channel

cochlear hair cell ribbon synapse
voltage-gated calcium channel activity involved SA node cell action potential
voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels
voltage-gated calcium channel activity involved in cardiac muscle cell action potential
induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration
positive regulation of presynaptic cytosolic calcium concentration
membrane depolarization during SA node cell action potential
regulation of atrial cardiac muscle cell membrane repolarization
SA node cell to atrial cardiac muscle cell signaling
SA node cell action potential
positive regulation of adenylate cyclase activity
positive regulation of synaptic vesicle exocytosis
SA node cell to atrial cardiac muscle cell communication
high voltage-gated calcium channel activity
L-type voltage-gated calcium channel complex
presynaptic modulation of chemical synaptic transmission
integral component of presynaptic active zone membrane
membrane depolarization during cardiac muscle cell action potential
regulation of presynaptic cytosolic calcium ion concentration
alpha-actinin binding
ankyrin binding
positive regulation of neurotransmitter secretion
positive regulation of cyclase activity
positive regulation of lyase activity
regulation of cardiac muscle cell membrane repolarization
cell-cell signaling involved in cardiac conduction
voltage-gated calcium channel complex
regulation of adenylate cyclase activity
membrane depolarization during action potential
regulation of membrane repolarization
neuron cellular homeostasis
regulation of heart rate by cardiac conduction
positive regulation of neurotransmitter transport
cardiac muscle cell action potential involved in contraction
voltage-gated calcium channel activity
cardiac muscle cell contraction
calcium ion import
regulation of cyclase activity
cell communication involved in cardiac conduction
regulation of lyase activity