CACNA1F

Gene Information

Official Symbol: CACNA1F
Official Name: calcium voltage-gated channel subunit alpha1 F
Aliases and Previous Symbols: N/A
Entrez ID: 778
UniProt: O60840
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a multipass transmembrane protein that functions as an alpha-1 subunit of the voltage-dependent calcium channel, which mediates the influx of calcium ions into the cell. The encoded protein forms a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Mutations in this gene can cause X-linked eye disorders, including congenital stationary night blindness type 2A, cone-rod dystropy, and Aland Island eye disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2013].
UniProt Summary: Isoform 1: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1F gives rise to L-type calcium currents. Long- lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin- IIIA (omega-Aga-IIIA). They are however insensitive to omega- conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga- IVA). Activates at more negative voltages and does not undergo calcium-dependent inactivation (CDI), due to incoming calcium ions, during depolarization. {ECO:0000269|PubMed:27226626}. Isoform 6: Voltage-dependent L-type calcium channel activates at more hyperpolarized voltages and exibits a robust calcium-dependent inactivation (CDI), due to incoming calcium ions, during depolarizations. {ECO:0000269|PubMed:27226626}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Hinokiflavone 12μM R08 exp487	-2.24
6-Thio-2-deoxyguanosine 2μM R06 exp259	-1.97
Lead acetate 2000μM R08 exp498 no dilution day6	-1.71
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	1.97

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5749
Expression level (log2 read counts): 1.25

Expression Distribution

PKD channel
Ion trans
Ca chan IQ

high voltage-gated calcium channel activity
detection of light stimulus involved in visual perception
detection of light stimulus involved in sensory perception
voltage-gated calcium channel complex
T cell homeostasis
regulation of T cell receptor signaling pathway
voltage-gated calcium channel activity
calcium ion import
detection of visible light
lymphocyte homeostasis
detection of light stimulus
photoreceptor outer segment
regulation of antigen receptor-mediated signaling pathway
leukocyte homeostasis
cardiac conduction
detection of external stimulus
detection of abiotic stimulus
perikaryon
multicellular organismal signaling
calcium ion transmembrane transport
homeostasis of number of cells
visual perception
sensory perception of light stimulus
regulation of heart contraction
calcium ion transport
regulation of blood circulation
divalent metal ion transport
divalent inorganic cation transport
response to light stimulus
response to radiation
regulation of ion transmembrane transport
detection of stimulus involved in sensory perception
inorganic cation transmembrane transport
regulation of transmembrane transport
regulation of system process
cation transmembrane transport
metal ion transport
inorganic ion transmembrane transport
detection of stimulus
regulation of ion transport