CACNA1G [The Human Chemical-Genetic Interaction Map Project]

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======= CACNA1G =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CACNA1G
  * **<color #00a2e8>Official Name</color>**: calcium voltage-gated channel subunit alpha1 G
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8913|8913]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43497|O43497]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CACNA1G&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CACNA1G|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604065|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Voltage-sensitive calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death. This gene encodes a T-type, low-voltage activated calcium channel. The T-type channels generate currents that are both transient, owing to fast inactivation, and tiny, owing to small conductance. T-type channels are thought to be involved in pacemaker activity, low-threshold calcium spikes, neuronal oscillations and resonance, and rebound burst firing. Many alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Sep 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PKD channel|
|Ion trans|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to nickel cation|
|voltage-gated calcium channel activity involved SA node cell action potential|
|low voltage-gated calcium channel activity|
|voltage-gated calcium channel activity involved in AV node cell action potential|
|membrane depolarization during AV node cell action potential|
|membrane depolarization during SA node cell action potential|
|AV node cell to bundle of His cell signaling|
|AV node cell action potential|
|regulation of atrial cardiac muscle cell membrane depolarization|
|SA node cell to atrial cardiac muscle cell signaling|
|SA node cell action potential|
|SA node cell to atrial cardiac muscle cell communication|
|AV node cell to bundle of His cell communication|
|membrane depolarization during cardiac muscle cell action potential|
|positive regulation of calcium ion-dependent exocytosis|
|cell-cell signaling involved in cardiac conduction|
|voltage-gated calcium channel complex|
|neuronal action potential|
|membrane depolarization during action potential|
|regulation of heart rate by cardiac conduction|
|cardiac muscle cell action potential involved in contraction|
|cardiac muscle cell contraction|
|regulation of calcium ion-dependent exocytosis|
|calcium ion import|
|cell communication involved in cardiac conduction|
|regulation of membrane depolarization|
|cardiac muscle cell action potential|
|membrane depolarization|
|positive regulation of regulated secretory pathway|
|transmission of nerve impulse|
|scaffold protein binding|
|cardiac muscle contraction|
|heart contraction|
|actin-mediated cell contraction|
|positive regulation of exocytosis|
|cardiac conduction|
|action potential|
|regulation of heart rate|
|heart process|
|striated muscle contraction|
|actin filament-based movement|
|multicellular organismal signaling|
|regulation of regulated secretory pathway|
|calcium ion transmembrane transport|
|regulation of exocytosis|
|regulation of heart contraction|
|calcium ion transport|
|muscle contraction|
|regulation of blood circulation|
|divalent metal ion transport|
|muscle system process|
|divalent inorganic cation transport|
|response to metal ion|
|blood circulation|
|circulatory system process|
|positive regulation of secretion by cell|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|regulation of membrane potential|
|positive regulation of secretion|
|trans-synaptic signaling|
|synaptic signaling|
|regulation of ion transmembrane transport|
|response to inorganic substance|
|regulation of vesicle-mediated transport|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|actin filament-based process|
|regulation of system process|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|regulation of ion transport|
|regulation of secretion by cell|
|ion homeostasis|
|regulation of secretion|
|cation transport|
|ion transmembrane transport|
|positive regulation of transport|
|chemical homeostasis|
|cell-cell signaling|
|transmembrane transport|
|ion transport|
|nervous system process|
|movement of cell or subcellular component|
|homeostatic process|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4578
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CACNA1G Expression in NALM6 Cells: 1.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>