CACNA1G

Gene Information

Official Symbol: CACNA1G
Official Name: calcium voltage-gated channel subunit alpha1 G
Aliases and Previous Symbols: N/A
Entrez ID: 8913
UniProt: O43497
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: Voltage-sensitive calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death. This gene encodes a T-type, low-voltage activated calcium channel. The T-type channels generate currents that are both transient, owing to fast inactivation, and tiny, owing to small conductance. T-type channels are thought to be involved in pacemaker activity, low-threshold calcium spikes, neuronal oscillations and resonance, and rebound burst firing. Many alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Sep 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4578
Expression level (log2 read counts): 1.06

Expression Distribution

PKD channel
Ion trans

response to nickel cation
voltage-gated calcium channel activity involved SA node cell action potential
low voltage-gated calcium channel activity
voltage-gated calcium channel activity involved in AV node cell action potential
membrane depolarization during AV node cell action potential
membrane depolarization during SA node cell action potential
AV node cell to bundle of His cell signaling
AV node cell action potential
regulation of atrial cardiac muscle cell membrane depolarization
SA node cell to atrial cardiac muscle cell signaling
SA node cell action potential
SA node cell to atrial cardiac muscle cell communication
AV node cell to bundle of His cell communication
membrane depolarization during cardiac muscle cell action potential
positive regulation of calcium ion-dependent exocytosis
cell-cell signaling involved in cardiac conduction
voltage-gated calcium channel complex
neuronal action potential
membrane depolarization during action potential
regulation of heart rate by cardiac conduction
cardiac muscle cell action potential involved in contraction
cardiac muscle cell contraction
regulation of calcium ion-dependent exocytosis
calcium ion import
cell communication involved in cardiac conduction
regulation of membrane depolarization
cardiac muscle cell action potential
membrane depolarization
positive regulation of regulated secretory pathway
transmission of nerve impulse
scaffold protein binding
cardiac muscle contraction
heart contraction
actin-mediated cell contraction
positive regulation of exocytosis
cardiac conduction
action potential
regulation of heart rate
heart process
striated muscle contraction