CACNA1I

Entrez Summary: This gene encodes the pore-forming alpha subunit of a voltage gated calcium channel. The encoded protein is a member of a subfamily of calcium channels referred to as is a low voltage-activated, T-type, calcium channel. The channel encoded by this protein is characterized by a slower activation and inactivation compared to other T-type calcium channels. This protein may be involved in calcium signaling in neurons. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

PKD channel
Ion trans

low voltage-gated calcium channel activity
sleep
positive regulation of calcium ion-dependent exocytosis
voltage-gated calcium channel complex
neuronal action potential
membrane depolarization during action potential
voltage-gated calcium channel activity
calcium ion import
regulation of calcium ion-dependent exocytosis
membrane depolarization
positive regulation of regulated secretory pathway
transmission of nerve impulse
flagellated sperm motility
sperm motility
positive regulation of exocytosis
cilium or flagellum-dependent cell motility
action potential
cilium-dependent cell motility
multicellular organismal signaling
regulation of regulated secretory pathway
calcium ion transmembrane transport
regulation of exocytosis
calcium ion transport
divalent metal ion transport
divalent inorganic cation transport
positive regulation of secretion by cell
regulation of membrane potential
positive regulation of secretion
regulation of ion transmembrane transport
regulation of vesicle-mediated transport
inorganic cation transmembrane transport
regulation of transmembrane transport
cation transmembrane transport
metal ion transport
inorganic ion transmembrane transport
regulation of ion transport
regulation of secretion by cell
regulation of secretion
cation transport
ion transmembrane transport