CACNG5 [The Human Chemical-Genetic Interaction Map Project]

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======= CACNG5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CACNG5
  * **<color #00a2e8>Official Name</color>**: calcium voltage-gated channel auxiliary subunit gamma 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27091|27091]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UF02|Q9UF02]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CACNG5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CACNG5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606405|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PMP22 Claudin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|neurotransmitter receptor transport, postsynaptic endosome to lysosome|
|channel regulator activity|
|receptor diffusion trapping|
|postsynaptic neurotransmitter receptor diffusion trapping|
|neurotransmitter receptor diffusion trapping|
|ion transmembrane transporter activity|
|regulation of postsynaptic neurotransmitter receptor activity|
|protein localization to postsynaptic specialization membrane|
|neurotransmitter receptor localization to postsynaptic specialization membrane|
|neurotransmitter receptor internalization|
|postsynaptic density membrane|
|regulation of AMPA receptor activity|
|AMPA glutamate receptor complex|
|positive regulation of synaptic transmission, glutamatergic|
|protein localization to postsynaptic membrane|
|neurotransmitter receptor transport|
|protein localization to lysosome|
|voltage-gated calcium channel activity|
|receptor localization to synapse|
|integral component of postsynaptic membrane|
|establishment of protein localization to vacuole|
|regulation of postsynaptic membrane neurotransmitter receptor levels|
|transmission of nerve impulse|
|protein localization to vacuole|
|receptor internalization|
|protein localization to synapse|
|regulation of glutamate receptor signaling pathway|
|regulation of synaptic transmission, glutamatergic|
|regulation of neurotransmitter receptor activity|
|localization within membrane|
|cardiac conduction|
|receptor metabolic process|
|lysosomal transport|
|multicellular organismal signaling|
|regulation of nervous system process|
|vacuolar transport|
|positive regulation of synaptic transmission|
|regulation of cation channel activity|
|regulation of signaling receptor activity|
|calcium ion transmembrane transport|
|protein localization to cell periphery|
|receptor-mediated endocytosis|
|regulation of heart contraction|
|calcium ion transport|
|postsynaptic density|
|protein-containing complex localization|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|regulation of transporter activity|
|regulation of blood circulation|
|divalent metal ion transport|
|divalent inorganic cation transport|
|regulation of cation transmembrane transport|
|glutamatergic synapse|
|establishment of protein localization to organelle|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|regulation of ion transmembrane transport|
|protein localization to membrane|
|cell junction|
|endocytosis|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|regulation of system process|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|import into cell|
|regulation of ion transport|
|protein localization to organelle|
|cation transport|
|ion transmembrane transport|
|transmembrane transport|
|ion transport|
|nervous system process|
|protein transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|positive regulation of cell communication|
|positive regulation of signaling|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4675
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CACNG5 Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>