CACNG5

Gene Information

Official Symbol: CACNG5
Official Name: calcium voltage-gated channel auxiliary subunit gamma 5
Aliases and Previous Symbols: N/A
Entrez ID: 27091
UniProt: Q9UF02
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4675
Expression level (log2 read counts): -6.6

Expression Distribution

neurotransmitter receptor transport, postsynaptic endosome to lysosome
channel regulator activity
receptor diffusion trapping
postsynaptic neurotransmitter receptor diffusion trapping
neurotransmitter receptor diffusion trapping
ion transmembrane transporter activity
regulation of postsynaptic neurotransmitter receptor activity
protein localization to postsynaptic specialization membrane
neurotransmitter receptor localization to postsynaptic specialization membrane
neurotransmitter receptor internalization
postsynaptic density membrane
regulation of AMPA receptor activity
AMPA glutamate receptor complex
positive regulation of synaptic transmission, glutamatergic
protein localization to postsynaptic membrane
neurotransmitter receptor transport
protein localization to lysosome
voltage-gated calcium channel activity
receptor localization to synapse
integral component of postsynaptic membrane
establishment of protein localization to vacuole
regulation of postsynaptic membrane neurotransmitter receptor levels
transmission of nerve impulse
protein localization to vacuole
receptor internalization
protein localization to synapse
regulation of glutamate receptor signaling pathway
regulation of synaptic transmission, glutamatergic
regulation of neurotransmitter receptor activity
localization within membrane
cardiac conduction
receptor metabolic process
lysosomal transport
multicellular organismal signaling
regulation of nervous system process
vacuolar transport
positive regulation of synaptic transmission
regulation of cation channel activity
regulation of signaling receptor activity
calcium ion transmembrane transport