CALCR

Gene Information

Official Symbol: CALCR
Official Name: calcitonin receptor
Aliases and Previous Symbols: N/A
Entrez ID: 799
UniProt: P30988
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9781
Expression level (log2 read counts): -7.68

Expression Distribution

Screen	Score
Dimethyl-Sulfoxide 1pc R03 exp120	-2.25
Cadmium 60μM R08 exp462	-1.92
LLY-283 2.6μM R06 exp290	1.94

HRM
7tm 2

calcitonin binding
calcitonin receptor activity
positive regulation of calcium ion import across plasma membrane
cross-receptor inhibition within G protein-coupled receptor heterodimer
amylin receptor complex 2
amylin receptor complex 1
amylin receptor complex 3
amylin receptor activity
calcitonin gene-related peptide receptor activity
regulation of calcium ion import across plasma membrane
amylin receptor signaling pathway
calcitonin family receptor signaling pathway
positive regulation of protein kinase A signaling
regulation of protein kinase A signaling
positive regulation of calcium ion import
activation of adenylate cyclase activity
regulation of calcium ion import
response to amyloid-beta
positive regulation of calcium ion transport into cytosol
negative regulation of signaling receptor activity
positive regulation of calcium ion transmembrane transport
amyloid-beta binding
regulation of calcium ion transport into cytosol
positive regulation of peptidyl-serine phosphorylation
positive regulation of calcium ion transport
adenylate cyclase-activating G protein-coupled receptor signaling pathway
regulation of peptidyl-serine phosphorylation
positive regulation of cation transmembrane transport
regulation of G protein-coupled receptor signaling pathway
response to glucocorticoid
cAMP-mediated signaling
regulation of calcium ion transmembrane transport
positive regulation of ion transmembrane transport
response to corticosteroid
positive regulation of protein kinase B signaling
cyclic-nucleotide-mediated signaling
regulation of signaling receptor activity
positive regulation of transmembrane transport
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
positive regulation of ERK1 and ERK2 cascade