CALY

Entrez Summary: N/A
UniProt Summary: Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis. {ECO:0000269|PubMed:16595675}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

postsynaptic endocytic zone
postsynaptic endocytosis
postsynaptic neurotransmitter receptor internalization
clathrin light chain binding
neurotransmitter receptor internalization
clathrin coat assembly
neurotransmitter receptor transport
dopamine receptor signaling pathway
regulation of postsynaptic membrane neurotransmitter receptor levels
receptor internalization
cellular response to dopamine
response to dopamine
signal transduction involved in cellular response to ammonium ion
positive regulation of endocytosis
cellular response to catecholamine stimulus
cellular response to monoamine stimulus
receptor metabolic process
response to catecholamine
response to monoamine
vesicle-mediated transport in synapse
cellular response to ammonium ion
cytoplasmic vesicle membrane
response to ammonium ion
regulation of endocytosis
endosomal transport
receptor-mediated endocytosis
cytoplasmic vesicle
protein-containing complex localization
protein-containing complex binding
endosome
glutamatergic synapse
cellular response to drug
establishment of protein localization to organelle
cellular response to organic cyclic compound
regulation of vesicle-mediated transport
endocytosis
cellular response to organonitrogen compound
cellular response to nitrogen compound
import into cell
protein localization to organelle