CAMTA1

Gene Information

Official Symbol: CAMTA1
Official Name: calmodulin binding transcription activator 1
Aliases and Previous Symbols: N/A
Entrez ID: 23261
UniProt: Q9Y6Y1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene contains a CG1 DNA-binding domain, a transcription factor immunoglobulin domain, ankyrin repeats, and calmodulin-binding IQ motifs. The encoded protein is thought to be a transcription factor and may be a tumor suppressor. However, a translocation event is sometimes observed between this gene and the WWTR1 gene, with the resulting WWTR1-CAMTA1 oncoprotein leading to epithelioid hemangioendothelioma, a malignant vascular cancer. [provided by RefSeq, Mar 2017].
UniProt Summary: Transcriptional activator. May act as a tumor suppressor. {ECO:0000269|PubMed:11925432, ECO:0000269|PubMed:15709179}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8828
Expression level (log2 read counts): 3.59

Expression Distribution

CG-1
TIG

positive regulation of calcineurin-NFAT signaling cascade
positive regulation of calcineurin-mediated signaling
regulation of calcineurin-mediated signaling
regulation of calcineurin-NFAT signaling cascade
positive regulation of calcium-mediated signaling
positive regulation of protein dephosphorylation
neuromuscular process controlling balance
positive regulation of dephosphorylation
regulation of calcium-mediated signaling
neuromuscular process
regulation of protein dephosphorylation
regulation of dephosphorylation
sequence-specific DNA binding
nucleolus
positive regulation of intracellular signal transduction
positive regulation of phosphorus metabolic process
positive regulation of phosphate metabolic process
positive regulation of transcription by RNA polymerase II
positive regulation of protein modification process
nervous system process
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
positive regulation of cellular protein metabolic process
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of signal transduction
positive regulation of protein metabolic process
positive regulation of RNA metabolic process
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
positive regulation of cell communication
positive regulation of signaling
regulation of intracellular signal transduction
regulation of protein modification process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
system process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process