CAND1 [The Human Chemical-Genetic Interaction Map Project]

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======= CAND1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CAND1
  * **<color #00a2e8>Official Name</color>**: cullin associated and neddylation dissociated 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55832|55832]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86VP6|Q86VP6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CAND1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CAND1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607727|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an essential regulator of Cullin-RING ubiquitin ligases, which are in involved in ubiquitinylation of proteins degraded by the Ub proteasome system. The encoded protein binds to unneddylated cullin-RING box protein complexes and acts as an inhibitor of cullin neddylation and of Skp1, cullin, and F box ubiquitin ligase complex assembly and activity. In mammalian cell culture, this protein predominantly localizes to the cytoplasm. Knockdown of this gene in preadipocytes results in blocked adipogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TIP120|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|SCF complex assembly|
|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|
|cullin-RING ubiquitin ligase complex|
|regulation of RNA polymerase II transcriptional preinitiation complex assembly|
|positive regulation of transcription initiation from RNA polymerase II promoter|
|TBP-class protein binding|
|positive regulation of DNA-templated transcription, initiation|
|regulation of transcription initiation from RNA polymerase II promoter|
|regulation of DNA-templated transcription, initiation|
|cellular iron ion homeostasis|
|iron ion homeostasis|
|ubiquitin ligase complex|
|cellular transition metal ion homeostasis|
|secretory granule lumen|
|ficolin-1-rich granule lumen|
|transition metal ion homeostasis|
|positive regulation of protein complex assembly|
|post-translational protein modification|
|regulation of protein complex assembly|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|positive regulation of cellular component biogenesis|
|myeloid cell activation involved in immune response|
|cellular metal ion homeostasis|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|metal ion homeostasis|
|cell activation involved in immune response|
|cellular cation homeostasis|
|cellular ion homeostasis|
|protein ubiquitination|
|regulated exocytosis|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|leukocyte mediated immunity|
|protein modification by small protein conjugation|
|ion homeostasis|
|negative regulation of catalytic activity|
|exocytosis|
|cellular homeostasis|
|leukocyte activation|
|regulation of cellular component biogenesis|
|Golgi apparatus|
|protein modification by small protein conjugation or removal|
|secretion by cell|
|export from cell|
|cell activation|
|immune effector process|
|chemical homeostasis|
|secretion|
|negative regulation of molecular function|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of transcription, DNA-templated|
|protein-containing complex assembly|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|positive regulation of RNA metabolic process|
|protein-containing complex subunit organization|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.74|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.1|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|2.13|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.17|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|2.29|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|3.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9067
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CAND1 Expression in NALM6 Cells: 7.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>