CAND1

Entrez Summary: This gene encodes an essential regulator of Cullin-RING ubiquitin ligases, which are in involved in ubiquitinylation of proteins degraded by the Ub proteasome system. The encoded protein binds to unneddylated cullin-RING box protein complexes and acts as an inhibitor of cullin neddylation and of Skp1, cullin, and F box ubiquitin ligase complex assembly and activity. In mammalian cell culture, this protein predominantly localizes to the cytoplasm. Knockdown of this gene in preadipocytes results in blocked adipogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

SCF complex assembly
positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
cullin-RING ubiquitin ligase complex
regulation of RNA polymerase II transcriptional preinitiation complex assembly
positive regulation of transcription initiation from RNA polymerase II promoter
TBP-class protein binding
positive regulation of DNA-templated transcription, initiation
regulation of transcription initiation from RNA polymerase II promoter
regulation of DNA-templated transcription, initiation
cellular iron ion homeostasis
iron ion homeostasis
ubiquitin ligase complex
cellular transition metal ion homeostasis
secretory granule lumen
ficolin-1-rich granule lumen
transition metal ion homeostasis
positive regulation of protein complex assembly
post-translational protein modification
regulation of protein complex assembly
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
positive regulation of cellular component biogenesis
myeloid cell activation involved in immune response
cellular metal ion homeostasis
myeloid leukocyte activation
leukocyte activation involved in immune response
metal ion homeostasis
cell activation involved in immune response
cellular cation homeostasis
cellular ion homeostasis
protein ubiquitination
regulated exocytosis
cation homeostasis
inorganic ion homeostasis
cellular chemical homeostasis