CAPN1 [The Human Chemical-Genetic Interaction Map Project]

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======= CAPN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CAPN1
  * **<color #00a2e8>Official Name</color>**: calpain 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=823|823]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P07384|P07384]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CAPN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CAPN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/114220|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. {ECO:0000269|PubMed:21531719, ECO:0000269|PubMed:2400579}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase C2|
|Calpain III|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mammary gland involution|
|self proteolysis|
|calcium-dependent cysteine-type endopeptidase activity|
|receptor catabolic process|
|regulation of NMDA receptor activity|
|mammary gland morphogenesis|
|regulation of glutamate receptor signaling pathway|
|extracellular matrix disassembly|
|regulation of neurotransmitter receptor activity|
|gland morphogenesis|
|tissue remodeling|
|receptor metabolic process|
|cornification|
|ficolin-1-rich granule lumen|
|mammary gland development|
|regulation of cation channel activity|
|regulation of signaling receptor activity|
|regulation of macroautophagy|
|keratinization|
|lysosome|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|keratinocyte differentiation|
|regulation of transporter activity|
|epidermal cell differentiation|
|regulation of autophagy|
|regulation of cation transmembrane transport|
|extracellular matrix organization|
|skin development|
|extracellular structure organization|
|cellular component disassembly|
|gland development|
|epidermis development|
|focal adhesion|
|regulation of ion transmembrane transport|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|regulation of transmembrane transport|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|epithelial cell differentiation|
|regulation of ion transport|
|regulated exocytosis|
|calcium ion binding|
|leukocyte mediated immunity|
|exocytosis|
|regulation of cellular catabolic process|
|positive regulation of cell population proliferation|
|leukocyte activation|
|animal organ morphogenesis|
|regulation of catabolic process|
|secretion by cell|
|export from cell|
|macromolecule catabolic process|
|programmed cell death|
|cell activation|
|cell death|
|immune effector process|
|epithelium development|
|secretion|
|mitochondrion|
|proteolysis|
|regulation of cell population proliferation|
|tissue development|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of transport|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|1.72|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.76|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|1.81|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7366
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CAPN1 Expression in NALM6 Cells: 6.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>