CAPN1

Entrez Summary: The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010].
UniProt Summary: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. {ECO:0000269|PubMed:21531719, ECO:0000269|PubMed:2400579}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
YM155 0.0002μM R01 exp61	1.72
GSK-J4 1.5μM R08 exp441	1.76
1-Methyl-nicotinamide-chloride 1000μM R03 exp113	1.81
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	1.88

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Peptidase C2
Calpain III

mammary gland involution
self proteolysis
calcium-dependent cysteine-type endopeptidase activity
receptor catabolic process
regulation of NMDA receptor activity
mammary gland morphogenesis
regulation of glutamate receptor signaling pathway
extracellular matrix disassembly
regulation of neurotransmitter receptor activity
gland morphogenesis
tissue remodeling
receptor metabolic process
cornification
ficolin-1-rich granule lumen
mammary gland development
regulation of cation channel activity
regulation of signaling receptor activity
regulation of macroautophagy
keratinization
lysosome
regulation of ion transmembrane transporter activity
regulation of transmembrane transporter activity
keratinocyte differentiation
regulation of transporter activity
epidermal cell differentiation
regulation of autophagy
regulation of cation transmembrane transport
extracellular matrix organization
skin development
extracellular structure organization
cellular component disassembly
gland development
epidermis development
focal adhesion
regulation of ion transmembrane transport
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation