CAPRIN2

Gene Information

Official Symbol: CAPRIN2
Official Name: caprin family member 2
Aliases and Previous Symbols: N/A
Entrez ID: 65981
UniProt: Q6IMN6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene may regulate the transport of mRNA. It may play a role in the differentiation of erythroblasts. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016].
UniProt Summary: Promotes phosphorylation of the Wnt coreceptor LRP6, leading to increased activity of the canonical Wnt signaling pathway (PubMed:18762581). Faciliates constitutive LRP6 phosphorylation by CDK14/CCNY during G2/M stage of the cell cycle, which may potentiate cells for Wnt signaling (PubMed:27821587). May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons (By similarity). Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation (PubMed:14593112). May be involved in apoptosis (PubMed:14593112). {ECO:0000250|UniProtKB:Q05A80, ECO:0000269|PubMed:14593112, ECO:0000269|PubMed:18762581, ECO:0000269|PubMed:27821587}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7499
Expression level (log2 read counts): 4.71

Expression Distribution

Screen	Score
Bisphenol F 50μM R08 exp457	-2.46
Momordin-Ic 10μM R08 exp506	1.76
Calcipotriol 5μM R08 exp464	1.9
Phenformin 20μM R03 exp143	1.98

C1q
Caprin-1 C

positive regulation of dendritic spine morphogenesis
positive regulation of dendrite morphogenesis
regulation of dendritic spine morphogenesis
positive regulation of dendritic spine development
regulation of dendritic spine development
positive regulation of dendrite development
regulation of dendrite morphogenesis
positive regulation of protein binding
regulation of postsynapse organization
positive regulation of peptidyl-serine phosphorylation
negative regulation of translation
regulation of peptidyl-serine phosphorylation
positive regulation of canonical Wnt signaling pathway
negative regulation of cellular amide metabolic process
regulation of dendrite development
positive regulation of cell morphogenesis involved in differentiation
positive regulation of Wnt signaling pathway
positive regulation of binding
negative regulation of cell growth
receptor complex
regulation of synapse organization
regulation of protein binding
regulation of synapse structure or activity
negative regulation of growth
positive regulation of neuron projection development
regulation of canonical Wnt signaling pathway
regulation of cell morphogenesis involved in differentiation
signaling receptor binding
regulation of translation
regulation of Wnt signaling pathway
positive regulation of neuron differentiation
regulation of binding
positive regulation of cell projection organization
regulation of cellular amide metabolic process
regulation of cell growth
positive regulation of neurogenesis
regulation of cell morphogenesis
centrosome
regulation of neuron projection development
posttranscriptional regulation of gene expression