CARKD

Entrez Summary: N/A
UniProt Summary: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. {ECO:0000255|HAMAP-Rule:MF_03157}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ADP-dependent NAD(P)H-hydrate dehydratase activity
ATP-dependent NAD(P)H-hydrate dehydratase activity
NAD biosynthesis via nicotinamide riboside salvage pathway
NAD biosynthetic process
nicotinamide nucleotide biosynthetic process
pyridine nucleotide biosynthetic process
nicotinamide nucleotide metabolic process
pyridine nucleotide metabolic process
pyridine-containing compound biosynthetic process
pyridine-containing compound metabolic process
oxidoreduction coenzyme metabolic process
coenzyme biosynthetic process
cofactor biosynthetic process
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
coenzyme metabolic process
mitochondrial matrix
cofactor metabolic process
nucleotide metabolic process
cellular component
nucleoside phosphate metabolic process
organophosphate biosynthetic process
nucleobase-containing small molecule metabolic process
molecular function
organophosphate metabolic process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
organonitrogen compound biosynthetic process
ATP binding
cellular nitrogen compound biosynthetic process
small molecule metabolic process