CASK

Entrez Summary: This gene encodes a calcium/calmodulin-dependent serine protein kinase. The encoded protein is a MAGUK (membrane-associated guanylate kinase) protein family member. These proteins are scaffold proteins and the encoded protein is located at synapses in the brain. Mutations in this gene are associated with FG syndrome 4, mental retardation and microcephaly with pontine and cerebellar hypoplasia, and a form of X-linked mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

nuclear lamina
guanylate kinase activity
GDP metabolic process
negative regulation of keratinocyte proliferation
neurexin family protein binding
GMP metabolic process
positive regulation of calcium ion import
regulation of keratinocyte proliferation
purine ribonucleoside monophosphate metabolic process
purine nucleoside monophosphate metabolic process
negative regulation of cell-matrix adhesion
regulation of calcium ion import
guanosine-containing compound metabolic process
calcium ion import
ribonucleoside monophosphate metabolic process
ciliary membrane
purine ribonucleoside metabolic process
negative regulation of cell-substrate adhesion
purine ribonucleoside diphosphate metabolic process
purine nucleoside diphosphate metabolic process
purine nucleoside metabolic process
ribonucleoside diphosphate metabolic process
negative regulation of wound healing
nucleoside monophosphate metabolic process
presynaptic membrane
ribonucleoside metabolic process
regulation of synaptic vesicle exocytosis
Schaffer collateral - CA1 synapse
nucleoside diphosphate metabolic process
negative regulation of response to wounding
basement membrane
signal release from synapse
neurotransmitter secretion
regulation of neurotransmitter secretion
nucleoside metabolic process
nuclear matrix
regulation of synaptic vesicle cycle
regulation of cell-matrix adhesion
positive regulation of calcium ion transport
negative regulation of epithelial cell proliferation