CBX5 [The Human Chemical-Genetic Interaction Map Project]

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======= CBX5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CBX5
  * **<color #00a2e8>Official Name</color>**: chromobox 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23468|23468]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P45973|P45973]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CBX5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CBX5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604478|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. {ECO:0000269|PubMed:19783980}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Chromo|
|Chromo shadow|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear pericentric heterochromatin|
|chromocenter|
|pericentric heterochromatin|
|site of DNA damage|
|nuclear heterochromatin|
|ribonucleoprotein complex binding|
|histone deacetylase complex|
|negative regulation of G0 to G1 transition|
|repressing transcription factor binding|
|histone methyltransferase complex|
|regulation of G0 to G1 transition|
|transcriptional repressor complex|
|methylated histone binding|
|protein binding, bridging|
|kinetochore|
|PML body|
|nuclear chromosome, telomeric region|
|histone deacetylase binding|
|ribonucleoprotein complex|
|nuclear envelope|
|protein-containing complex binding|
|blood coagulation|
|coagulation|
|hemostasis|
|negative regulation of cell cycle process|
|chromatin binding|
|wound healing|
|regulation of body fluid levels|
|response to wounding|
|negative regulation of cell cycle|
|protein-containing complex|
|viral process|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|symbiotic process|
|interspecies interaction between organisms|
|nucleolus|
|negative regulation of transcription by RNA polymerase II|
|protein homodimerization activity|
|identical protein binding|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|cellular response to stress|
|negative regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-2.8|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-2.35|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-2.28|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-2.1|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-1.79|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-1.76|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-1.7|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3434
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CBX5 Expression in NALM6 Cells: 9.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>