CBX5

Entrez Summary: N/A
UniProt Summary: Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. {ECO:0000269|PubMed:19783980}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
THZ531 0.11 to 0.125μM on day4 R07 exp410	-2.8
THZ531 0.11 to 0.175μM on day4 R07 exp413	-2.35
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-2.28
EPZ-5676 30μM R05 exp233	-2.1
Rapamycin 2μM plus FK-506 5μM R07 exp308	-1.79
Milciclib 2μM R08 exp502	-1.76
Quercetin 20μM R08 exp517	-1.7
TRAIL 50ng/ml R00 exp36	1.82

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Chromo
Chromo shadow

nuclear pericentric heterochromatin
chromocenter
pericentric heterochromatin
site of DNA damage
nuclear heterochromatin
ribonucleoprotein complex binding
histone deacetylase complex
negative regulation of G0 to G1 transition
repressing transcription factor binding
histone methyltransferase complex
regulation of G0 to G1 transition
transcriptional repressor complex
methylated histone binding
protein binding, bridging
kinetochore
PML body
nuclear chromosome, telomeric region
histone deacetylase binding
ribonucleoprotein complex
nuclear envelope
protein-containing complex binding
blood coagulation
coagulation
hemostasis
negative regulation of cell cycle process
chromatin binding
wound healing
regulation of body fluid levels
response to wounding
negative regulation of cell cycle
protein-containing complex
viral process
regulation of cell cycle process
cellular response to DNA damage stimulus
symbiotic process
interspecies interaction between organisms
nucleolus
negative regulation of transcription by RNA polymerase II
protein homodimerization activity
identical protein binding