CCBE1

Entrez Summary: This gene is thought to function in extracellular matrix remodeling and migration. It is predominantly expressed in the ovary, but down regulated in ovarian cancer cell lines and primary carcinomas, suggesting its role as a tumour suppressor. Mutations in this gene have been associated with Hennekam lymphangiectasia-lymphedema syndrome, a generalized lymphatic dysplasia in humans. [provided by RefSeq, Mar 2010].
UniProt Summary: Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis. {ECO:0000269|PubMed:19935664}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

EGF CA
Collagen

positive regulation of lymphangiogenesis
regulation of lymphangiogenesis
positive regulation of vascular endothelial growth factor signaling pathway
venous blood vessel morphogenesis
lymphangiogenesis
respiratory system process
venous blood vessel development
lymph vessel morphogenesis
regulation of vascular endothelial growth factor signaling pathway
regulation of cellular response to vascular endothelial growth factor stimulus
lymph vessel development
positive regulation of protein processing
positive regulation of protein maturation
positive regulation of vascular endothelial growth factor production
regulation of vascular endothelial growth factor production
respiratory gaseous exchange by respiratory system
sprouting angiogenesis
collagen trimer
collagen binding
regulation of protein processing
regulation of protein maturation
positive regulation of endothelial cell migration
protease binding
positive regulation of epithelial cell migration
regulation of endothelial cell migration
positive regulation of angiogenesis
lung development
respiratory tube development
positive regulation of vasculature development
respiratory system development
regulation of epithelial cell migration
extracellular matrix
regulation of cellular response to growth factor stimulus
regulation of angiogenesis
angiogenesis
regulation of vasculature development
positive regulation of proteolysis
blood vessel morphogenesis
positive regulation of cytokine production
blood vessel development