CCDC3

Entrez Summary: N/A
UniProt Summary: Negatively regulates TNF-alpha-induced pro-inflammatory response in endothelial cells (ECs) via inhibition of TNF-alpha- induced NF-kappaB activation in ECs (PubMed:25193116). Positively regulates lipid accumulation in adipose cells (By similarity). {ECO:0000250|UniProtKB:Q9D6Y1, ECO:0000269|PubMed:25193116}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of tumor necrosis factor-mediated signaling pathway
regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of fat cell differentiation
negative regulation of cytokine-mediated signaling pathway
negative regulation of response to cytokine stimulus
positive regulation of lipid biosynthetic process
regulation of fat cell differentiation
positive regulation of lipid metabolic process
regulation of cytokine-mediated signaling pathway
regulation of response to cytokine stimulus
regulation of lipid biosynthetic process
regulation of lipid metabolic process
positive regulation of cell differentiation
endoplasmic reticulum
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
positive regulation of developmental process
negative regulation of response to stimulus
regulation of cell differentiation
extracellular region
positive regulation of biosynthetic process