CCDC65

Entrez Summary: This gene encodes a sperm tail protein that is highly expressed in adult testis, spermatocytes and spermatids. The protein plays a critical role in the assembly of the nexin-dynein regulatory complex. Mutations in this gene result in primary ciliary dyskinesia. [provided by RefSeq, Nov 2013].
UniProt Summary: May play a role in motile cilia function, possibly by acting on the assembly of the nexin-dynein regulatory complex. {ECO:0000269|PubMed:24094744}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

axonemal dynein complex
regulation of cilium movement
regulation of microtubule-based movement
axonemal dynein complex assembly
axoneme assembly
microtubule bundle formation
cilium-dependent cell motility
cilium or flagellum-dependent cell motility
motile cilium
axoneme
regulation of microtubule-based process
cilium assembly
cilium organization
plasma membrane bounded cell projection assembly
cellular component
cell projection assembly
microtubule cytoskeleton organization
microtubule-based process
organelle assembly
molecular function
cellular protein-containing complex assembly
regulation of cellular component movement
cell motility
localization of cell
cytoskeleton organization
plasma membrane bounded cell projection organization
cell projection organization
locomotion
movement of cell or subcellular component
protein-containing complex assembly
protein-containing complex subunit organization