CCDC90B [The Human Chemical-Genetic Interaction Map Project]

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======= CCDC90B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCDC90B
  * **<color #00a2e8>Official Name</color>**: coiled-coil domain containing 90B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=60492|60492]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9GZT6|Q9GZT6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCDC90B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCDC90B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620753|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF1640|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial membrane|
|mitochondrion|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp83|Trametinib 10μM R02 exp83]]|1.74|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.77|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|1.78|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|1.81|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|1.96|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|2.02|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.06|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.09|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|2.16|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|2.19|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|2.21|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|2.27|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|2.56|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prepl|PREPL]]|0.482|
|[[:human genes:m:mcur1|MCUR1]]|0.468|
|[[:human genes:m:mpv17l2|MPV17L2]]|0.465|
|[[:human genes:f:fastkd2|FASTKD2]]|0.456|
|[[:human genes:a:agpat5|AGPAT5]]|0.437|
|[[:human genes:r:rexo2|REXO2]]|0.421|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.414|
|[[:human genes:r:rmnd1|RMND1]]|0.409|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 907
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCDC90B Expression in NALM6 Cells: 5.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>