CCK [The Human Chemical-Genetic Interaction Map Project]

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======= CCK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCK
  * **<color #00a2e8>Official Name</color>**: cholecystokinin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=885|885]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P06307|P06307]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/118440|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Gastrin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of fear response|
|negative regulation of behavioral fear response|
|negative regulation of eating behavior|
|positive regulation of fear response|
|positive regulation of behavioral fear response|
|positive regulation of sensory perception of pain|
|regulation of eating behavior|
|axon hillock|
|regulation of fear response|
|regulation of behavioral fear response|
|positive regulation of mitochondrial depolarization|
|negative regulation of feeding behavior|
|peptide hormone receptor binding|
|positive regulation of glutamate secretion|
|positive regulation of membrane depolarization|
|negative regulation of response to food|
|negative regulation of appetite|
|negative regulation of response to nutrient levels|
|negative regulation of response to extracellular stimulus|
|regulation of glutamate secretion|
|negative regulation of behavior|
|positive regulation of amino acid transport|
|regulation of response to food|
|axon initial segment|
|regulation of mitochondrial depolarization|
|release of cytochrome c from mitochondria|
|regulation of appetite|
|regulation of response to extracellular stimulus|
|regulation of response to nutrient levels|
|positive regulation of protein oligomerization|
|regulation of feeding behavior|
|neuropeptide hormone activity|
|protein kinase C-activating G protein-coupled receptor signaling pathway|
|positive regulation of behavior|
|eating behavior|
|regulation of amino acid transport|
|positive regulation of organic acid transport|
|positive regulation of amine transport|
|regulation of sensory perception of pain|
|regulation of sensory perception|
|regulation of protein oligomerization|
|regulation of membrane depolarization|
|visual learning|
|terminal bouton|
|positive regulation of anion transport|
|visual behavior|
|regulation of organic acid transport|
|apoptotic mitochondrial changes|
|positive regulation of nervous system process|
|regulation of mitochondrial membrane potential|
|regulation of behavior|
|associative learning|
|feeding behavior|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of amine transport|
|regulation of anion transport|
|hormone activity|
|digestion|
|memory|
|neuron migration|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|perikaryon|
|regulation of nervous system process|
|learning|
|positive regulation of cysteine-type endopeptidase activity|
|positive regulation of endopeptidase activity|
|positive regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of peptidase activity|
|negative regulation of defense response|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of cysteine-type endopeptidase activity|
|positive regulation of protein complex assembly|
|regulation of peptidyl-tyrosine phosphorylation|
|learning or memory|
|positive regulation of ion transport|
|apoptotic signaling pathway|
|axon|
|cognition|
|response to light stimulus|
|positive regulation of proteolysis|
|negative regulation of response to external stimulus|
|axonogenesis|
|positive regulation of secretion by cell|
|axon development|
|regulation of endopeptidase activity|
|dendrite|
|regulation of membrane potential|
|cell morphogenesis involved in neuron differentiation|
|positive regulation of secretion|
|response to radiation|
|mitochondrion organization|
|regulation of peptidase activity|
|regulation of protein complex assembly|
|positive regulation of defense response|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|response to nutrient levels|
|cell part morphogenesis|
|positive regulation of cellular component biogenesis|
|response to extracellular stimulus|
|cell morphogenesis involved in differentiation|
|behavior|
|regulation of system process|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|neuron projection development|
|positive regulation of cell death|
|regulation of ion transport|
|cell morphogenesis|
|regulation of proteolysis|
|regulation of secretion by cell|
|regulation of defense response|
|positive regulation of hydrolase activity|
|ion homeostasis|
|regulation of secretion|
|neuron development|
|cellular component morphogenesis|
|positive regulation of cell population proliferation|
|apoptotic process|
|regulation of cellular component biogenesis|
|cell migration|
|positive regulation of transport|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|programmed cell death|
|positive regulation of phosphorylation|
|cell motility|
|localization of cell|
|cell death|
|regulation of response to external stimulus|
|chemical homeostasis|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|response to abiotic stimulus|
|cell projection organization|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|locomotion|
|G protein-coupled receptor signaling pathway|
|nervous system process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|generation of neurons|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|homeostatic process|
|cell development|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|regulation of transport|
|extracellular region|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.1|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7337
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCK Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>