CCK
Gene Information
- Official Symbol: CCK
- Official Name: cholecystokinin
- Aliases and Previous Symbols: N/A
- Entrez ID: 885
- UniProt: P06307
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.
Pfam Domains GO Terms
Pfam Domains
| Gastrin |
GO Terms
| negative regulation of fear response |
| negative regulation of behavioral fear response |
| negative regulation of eating behavior |
| positive regulation of fear response |
| positive regulation of behavioral fear response |
| positive regulation of sensory perception of pain |
| regulation of eating behavior |
| axon hillock |
| regulation of fear response |
| regulation of behavioral fear response |
| positive regulation of mitochondrial depolarization |
| negative regulation of feeding behavior |
| peptide hormone receptor binding |
| positive regulation of glutamate secretion |
| positive regulation of membrane depolarization |
| negative regulation of response to food |
| negative regulation of appetite |
| negative regulation of response to nutrient levels |
| negative regulation of response to extracellular stimulus |
| regulation of glutamate secretion |
| negative regulation of behavior |
| positive regulation of amino acid transport |
| regulation of response to food |
| axon initial segment |
| regulation of mitochondrial depolarization |
| release of cytochrome c from mitochondria |
| regulation of appetite |
| regulation of response to extracellular stimulus |
| regulation of response to nutrient levels |
| positive regulation of protein oligomerization |
| regulation of feeding behavior |
| neuropeptide hormone activity |
| protein kinase C-activating G protein-coupled receptor signaling pathway |
| positive regulation of behavior |
| eating behavior |
| regulation of amino acid transport |
| positive regulation of organic acid transport |
| positive regulation of amine transport |
| regulation of sensory perception of pain |
| regulation of sensory perception |
| regulation of protein oligomerization |
| regulation of membrane depolarization |
| visual learning |
| terminal bouton |
| positive regulation of anion transport |
| visual behavior |
| regulation of organic acid transport |
| apoptotic mitochondrial changes |
| positive regulation of nervous system process |
| regulation of mitochondrial membrane potential |
| regulation of behavior |
| associative learning |
| feeding behavior |
| activation of cysteine-type endopeptidase activity involved in apoptotic process |
| regulation of amine transport |
| regulation of anion transport |
| hormone activity |
| digestion |
| memory |
| neuron migration |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| perikaryon |
| regulation of nervous system process |
| learning |
| positive regulation of cysteine-type endopeptidase activity |
| positive regulation of endopeptidase activity |
| positive regulation of peptidyl-tyrosine phosphorylation |
| positive regulation of peptidase activity |
| negative regulation of defense response |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| regulation of cysteine-type endopeptidase activity |
| positive regulation of protein complex assembly |
| regulation of peptidyl-tyrosine phosphorylation |
| learning or memory |
| positive regulation of ion transport |
| apoptotic signaling pathway |
| axon |
| cognition |
| response to light stimulus |
| positive regulation of proteolysis |
| negative regulation of response to external stimulus |
| axonogenesis |
| positive regulation of secretion by cell |
| axon development |
| regulation of endopeptidase activity |
| dendrite |
| regulation of membrane potential |
| cell morphogenesis involved in neuron differentiation |
| positive regulation of secretion |
| response to radiation |
| mitochondrion organization |
| regulation of peptidase activity |
| regulation of protein complex assembly |
| positive regulation of defense response |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| response to nutrient levels |
| cell part morphogenesis |
| positive regulation of cellular component biogenesis |
| response to extracellular stimulus |
| cell morphogenesis involved in differentiation |
| behavior |
| regulation of system process |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| neuron projection development |
| positive regulation of cell death |
| regulation of ion transport |
| cell morphogenesis |
| regulation of proteolysis |
| regulation of secretion by cell |
| regulation of defense response |
| positive regulation of hydrolase activity |
| ion homeostasis |
| regulation of secretion |
| neuron development |
| cellular component morphogenesis |
| positive regulation of cell population proliferation |
| apoptotic process |
| regulation of cellular component biogenesis |
| cell migration |
| positive regulation of transport |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| programmed cell death |
| positive regulation of phosphorylation |
| cell motility |
| localization of cell |
| cell death |
| regulation of response to external stimulus |
| chemical homeostasis |
| plasma membrane bounded cell projection organization |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| response to abiotic stimulus |
| cell projection organization |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| positive regulation of protein modification process |
| regulation of hydrolase activity |
| locomotion |
| G protein-coupled receptor signaling pathway |
| nervous system process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| generation of neurons |
| regulation of apoptotic process |
| movement of cell or subcellular component |
| regulation of programmed cell death |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| homeostatic process |
| cell development |
| regulation of cell death |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of protein modification process |
| regulation of transport |
| extracellular region |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| THZ1 0.06μM R08 exp531 | 2.1 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7337
- Expression level (log2 read counts): -7.68
Expression Distribution
CCK Expression in NALM6 Cells: -7.68
